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Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study.
Gut 1997; 40(3):313-9Gut

Abstract

BACKGROUND

Patients with inflammatory bowel disease are at risk of developing metabolic bone disease.

AIMS

To compare bone mineral density in patients with Crohn's disease with patients with ulcerative colitis and healthy subjects, and to evaluate possible risk factors for bone loss in inflammatory bowel disease.

PATIENTS

60 patients with Crohn's disease, 60 with ulcerative colitis, and 60 healthy subjects were investigated. Each group consisted of 24 men and 36 women.

METHODS

Lumbar spine, femoral neck, and total body bone mineral density were measured by dual x ray absorptiometry (DXA), and Z scores were obtained by comparison with age and sex matched normal values.

RESULTS

Mean Z scores were significantly lower in patients with Crohn's disease compared with patients with ulcerative colitis and healthy subjects. Patients with ulcerative colitis had bone mineral densities similar to healthy subjects. Use of corticosteroids, body mass index (BMI), and sex were significant predictor variables for bone mineral density in Crohn's disease. In ulcerative colitis only body mass index and sex were of significant importance. Disease localisation and small bowel resections had no influence on bone mineral density in patients with Crohn's disease.

CONCLUSIONS

Patients with Crohn's disease have reduced bone mineral density. Several factors are probably involved, but the reduction is associated with corticosteroid therapy. When studying skeletal effects of inflammatory bowel disease, patients with Crohn's disease and those with ulcerative colitis should be evaluated separately.

Authors+Show Affiliations

Medical Department, Aker University Hospital, Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9135518

Citation

Jahnsen, J, et al. "Bone Mineral Density Is Reduced in Patients With Crohn's Disease but Not in Patients With Ulcerative Colitis: a Population Based Study." Gut, vol. 40, no. 3, 1997, pp. 313-9.
Jahnsen J, Falch JA, Aadland E, et al. Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study. Gut. 1997;40(3):313-9.
Jahnsen, J., Falch, J. A., Aadland, E., & Mowinckel, P. (1997). Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study. Gut, 40(3), pp. 313-9.
Jahnsen J, et al. Bone Mineral Density Is Reduced in Patients With Crohn's Disease but Not in Patients With Ulcerative Colitis: a Population Based Study. Gut. 1997;40(3):313-9. PubMed PMID: 9135518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study. AU - Jahnsen,J, AU - Falch,J A, AU - Aadland,E, AU - Mowinckel,P, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 313 EP - 9 JF - Gut JO - Gut VL - 40 IS - 3 N2 - BACKGROUND: Patients with inflammatory bowel disease are at risk of developing metabolic bone disease. AIMS: To compare bone mineral density in patients with Crohn's disease with patients with ulcerative colitis and healthy subjects, and to evaluate possible risk factors for bone loss in inflammatory bowel disease. PATIENTS: 60 patients with Crohn's disease, 60 with ulcerative colitis, and 60 healthy subjects were investigated. Each group consisted of 24 men and 36 women. METHODS: Lumbar spine, femoral neck, and total body bone mineral density were measured by dual x ray absorptiometry (DXA), and Z scores were obtained by comparison with age and sex matched normal values. RESULTS: Mean Z scores were significantly lower in patients with Crohn's disease compared with patients with ulcerative colitis and healthy subjects. Patients with ulcerative colitis had bone mineral densities similar to healthy subjects. Use of corticosteroids, body mass index (BMI), and sex were significant predictor variables for bone mineral density in Crohn's disease. In ulcerative colitis only body mass index and sex were of significant importance. Disease localisation and small bowel resections had no influence on bone mineral density in patients with Crohn's disease. CONCLUSIONS: Patients with Crohn's disease have reduced bone mineral density. Several factors are probably involved, but the reduction is associated with corticosteroid therapy. When studying skeletal effects of inflammatory bowel disease, patients with Crohn's disease and those with ulcerative colitis should be evaluated separately. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9135518/Bone_mineral_density_is_reduced_in_patients_with_Crohn's_disease_but_not_in_patients_with_ulcerative_colitis:_a_population_based_study_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=9135518 DB - PRIME DP - Unbound Medicine ER -