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The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application.
Anticancer Res. 1997 Mar-Apr; 17(2B):1255-72.AR

Abstract

In this review an overview is given of the possible applications and usefulness of the beta-core fragment of hCG (beta cf-hCG) as an urinary tumor marker. Expression of human Chorionic Gonadotropin (hCG) is an important indicator of malignant transformation. The biochemical background of this glycoprotein hormone and the degradation pathway towards beta cf-hCG is described. There are two main pathways: peripheral degradation in the serum and the renal parenchymal degradation. HCG and its subunits show immunoreactivity and cross-reactivity with other glycoprotein hormones and their subunits. The different "in house" methods to determine beta cf-hCG developed and used by various research institutes are described. In various types of cancer, concentrations of hCG as well as its beta-subunit may be elevated, allowing the clinical use of these substances as a tumor marker. The relation between laboratory outcome and clinical status is assessed, with emphasis on the beta cf-hCG in gynecological malignancies. The limitations of the use of beta cf-hCG as a tumor marker are discussed. The stability of beta cf-hCG may allow distant follow-up in samples sent to the laboratory by mail.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Academic Hospital Free University, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9137483

Citation

Schutter, E M., et al. "The Beta-core Fragment of Human Chorionic Gonadotropin: Biochemical Background and Clinical Application." Anticancer Research, vol. 17, no. 2B, 1997, pp. 1255-72.
Schutter EM, Mulder C, van Kamp GJ, et al. The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application. Anticancer Res. 1997;17(2B):1255-72.
Schutter, E. M., Mulder, C., van Kamp, G. J., & Kenemans, P. (1997). The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application. Anticancer Research, 17(2B), 1255-72.
Schutter EM, et al. The Beta-core Fragment of Human Chorionic Gonadotropin: Biochemical Background and Clinical Application. Anticancer Res. 1997 Mar-Apr;17(2B):1255-72. PubMed PMID: 9137483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The beta-core fragment of human chorionic gonadotropin: biochemical background and clinical application. AU - Schutter,E M, AU - Mulder,C, AU - van Kamp,G J, AU - Kenemans,P, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 1255 EP - 72 JF - Anticancer research JO - Anticancer Res VL - 17 IS - 2B N2 - In this review an overview is given of the possible applications and usefulness of the beta-core fragment of hCG (beta cf-hCG) as an urinary tumor marker. Expression of human Chorionic Gonadotropin (hCG) is an important indicator of malignant transformation. The biochemical background of this glycoprotein hormone and the degradation pathway towards beta cf-hCG is described. There are two main pathways: peripheral degradation in the serum and the renal parenchymal degradation. HCG and its subunits show immunoreactivity and cross-reactivity with other glycoprotein hormones and their subunits. The different "in house" methods to determine beta cf-hCG developed and used by various research institutes are described. In various types of cancer, concentrations of hCG as well as its beta-subunit may be elevated, allowing the clinical use of these substances as a tumor marker. The relation between laboratory outcome and clinical status is assessed, with emphasis on the beta cf-hCG in gynecological malignancies. The limitations of the use of beta cf-hCG as a tumor marker are discussed. The stability of beta cf-hCG may allow distant follow-up in samples sent to the laboratory by mail. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/9137483/The_beta_core_fragment_of_human_chorionic_gonadotropin:_biochemical_background_and_clinical_application_ DB - PRIME DP - Unbound Medicine ER -