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Oncotic, hemodilutional, and hemostatic effects of isotonic saline and hydroxyethyl starch solutions in clinically normal ponies.
Am J Vet Res. 1997 May; 58(5):541-8.AJ

Abstract

OBJECTIVE

To evaluate the oncotic, hemodilutional, and hemostatic effects of IV infusions of a large volume of isotonic saline solution and 2 doses of 6% hydroxyethyl starch (HES) in clinically normal ponies.

ANIMALS

12 adult ponies.

PROCEDURE

Ponies were assigned to 3 treatment groups and received the following IV infusions: 80 ml of 0.9% sodium chloride/kg; 10 ml of 6% HES (in 0.9% sodium chloride)/kg; or 20 ml of 6% HES (in 0.9% sodium chloride)/kg. Blood samples were collected for determination of colloid oncotic pressure (COP), PCV, plasma total protein concentration, platelet count, von Willebrand factor antigen (vWf:Ag) activity, fibrinogen concentration, prothrombin time, activated partial thromboplastin time (APTT), and factor VIII coagulant (FVIII:C) activity. A rocket immunoelectrophoretic procedure was used for determination of vWf:Ag activity. A modification of the APTT assay was used for determination of FVIII:C activity. Cutaneous bleeding time was determined, using a template method.

RESULTS

Mean COP was persistently increased over baseline values in the face of hemodilution in HES-treated ponies. Prothrombin time, APTT, and fibrinogen concentrations decreased after infusions and vWf:Ag and FVIII:C activities were decreased in dose-dependent manner in HES-treated ponies. Though cutaneous bleeding time was not significantly affected in ponies of any group, a trend toward prolongation of bleeding time was evident in ponies receiving 20 ml of HES/kg. This trend appeared to be associated with marked decrement in vWf:Ag activity at this dosage.

CONCLUSIONS AND CLINICAL RELEVANCE

Infusion of HES in clinically normal ponies increases COP, and exerts dose-dependent hemodilutional effects and dose-dependent effects on specific hemostatic variables. Thus, HES may be useful for resuscitative fluid treatment of horses.

Authors+Show Affiliations

Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square 19348-1692, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9140565

Citation

Jones, P A., et al. "Oncotic, Hemodilutional, and Hemostatic Effects of Isotonic Saline and Hydroxyethyl Starch Solutions in Clinically Normal Ponies." American Journal of Veterinary Research, vol. 58, no. 5, 1997, pp. 541-8.
Jones PA, Tomasic M, Gentry PA. Oncotic, hemodilutional, and hemostatic effects of isotonic saline and hydroxyethyl starch solutions in clinically normal ponies. Am J Vet Res. 1997;58(5):541-8.
Jones, P. A., Tomasic, M., & Gentry, P. A. (1997). Oncotic, hemodilutional, and hemostatic effects of isotonic saline and hydroxyethyl starch solutions in clinically normal ponies. American Journal of Veterinary Research, 58(5), 541-8.
Jones PA, Tomasic M, Gentry PA. Oncotic, Hemodilutional, and Hemostatic Effects of Isotonic Saline and Hydroxyethyl Starch Solutions in Clinically Normal Ponies. Am J Vet Res. 1997;58(5):541-8. PubMed PMID: 9140565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oncotic, hemodilutional, and hemostatic effects of isotonic saline and hydroxyethyl starch solutions in clinically normal ponies. AU - Jones,P A, AU - Tomasic,M, AU - Gentry,P A, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 541 EP - 8 JF - American journal of veterinary research JO - Am J Vet Res VL - 58 IS - 5 N2 - OBJECTIVE: To evaluate the oncotic, hemodilutional, and hemostatic effects of IV infusions of a large volume of isotonic saline solution and 2 doses of 6% hydroxyethyl starch (HES) in clinically normal ponies. ANIMALS: 12 adult ponies. PROCEDURE: Ponies were assigned to 3 treatment groups and received the following IV infusions: 80 ml of 0.9% sodium chloride/kg; 10 ml of 6% HES (in 0.9% sodium chloride)/kg; or 20 ml of 6% HES (in 0.9% sodium chloride)/kg. Blood samples were collected for determination of colloid oncotic pressure (COP), PCV, plasma total protein concentration, platelet count, von Willebrand factor antigen (vWf:Ag) activity, fibrinogen concentration, prothrombin time, activated partial thromboplastin time (APTT), and factor VIII coagulant (FVIII:C) activity. A rocket immunoelectrophoretic procedure was used for determination of vWf:Ag activity. A modification of the APTT assay was used for determination of FVIII:C activity. Cutaneous bleeding time was determined, using a template method. RESULTS: Mean COP was persistently increased over baseline values in the face of hemodilution in HES-treated ponies. Prothrombin time, APTT, and fibrinogen concentrations decreased after infusions and vWf:Ag and FVIII:C activities were decreased in dose-dependent manner in HES-treated ponies. Though cutaneous bleeding time was not significantly affected in ponies of any group, a trend toward prolongation of bleeding time was evident in ponies receiving 20 ml of HES/kg. This trend appeared to be associated with marked decrement in vWf:Ag activity at this dosage. CONCLUSIONS AND CLINICAL RELEVANCE: Infusion of HES in clinically normal ponies increases COP, and exerts dose-dependent hemodilutional effects and dose-dependent effects on specific hemostatic variables. Thus, HES may be useful for resuscitative fluid treatment of horses. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/9140565/Oncotic_hemodilutional_and_hemostatic_effects_of_isotonic_saline_and_hydroxyethyl_starch_solutions_in_clinically_normal_ponies_ DB - PRIME DP - Unbound Medicine ER -