Tags

Type your tag names separated by a space and hit enter

Sensitivity to the motoric effects of a dopamine receptor antagonist differs as a function of age at the time of dopamine depletion.
Dev Psychobiol. 1997 May; 30(4):293-300.DP

Abstract

The ability of the mixed D1/D2 dopamine (DA) receptor antagonist cis-flupentixol to impair locomotor behavior in adult rats depleted of DA as weanlings was determined. Rats received lateral ventricular injections of 6-hydroxydopamine (100-200 micrograms/hemisphere) or its vehicle solution on postnatal Day 20, 27, or 35. We compared the ability of cis-flupentixol (.06, .25, and 1.0 mg/kg. i.p.) to impair the initiation of voluntary locomotion (i.e., akinesia) in control and DA-depleted subjects. Despite the fact that analyses of tissue homogenates revealed comparably large (93-96%) depletions of striatal DA across the three ages, the lesioned animals differed markedly in their sensitivity to the behavioral effects of the receptor antagonist. Surprisingly, rats depleted of DA on Day 20 or 27 were no more sensitive than vehicle-treated controls to the akinesia-inducing effects of each dose of flupentixol. In contrast, rats depleted of DA on Day 35 were supersensitive to the effects of the drug as they exhibited akinesia after a low dose of flupentixol that had no effect in any controls or animals depleted of DA at younger ages. These results suggest clear age-dependent differences in the plasticity of residual striatal DA neurons following subtotal damage.

Authors+Show Affiliations

Department of Psychology, Ohio State University Columbus 43210, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9142505

Citation

Sandstrom, M I., and J P. Bruno. "Sensitivity to the Motoric Effects of a Dopamine Receptor Antagonist Differs as a Function of Age at the Time of Dopamine Depletion." Developmental Psychobiology, vol. 30, no. 4, 1997, pp. 293-300.
Sandstrom MI, Bruno JP. Sensitivity to the motoric effects of a dopamine receptor antagonist differs as a function of age at the time of dopamine depletion. Dev Psychobiol. 1997;30(4):293-300.
Sandstrom, M. I., & Bruno, J. P. (1997). Sensitivity to the motoric effects of a dopamine receptor antagonist differs as a function of age at the time of dopamine depletion. Developmental Psychobiology, 30(4), 293-300.
Sandstrom MI, Bruno JP. Sensitivity to the Motoric Effects of a Dopamine Receptor Antagonist Differs as a Function of Age at the Time of Dopamine Depletion. Dev Psychobiol. 1997;30(4):293-300. PubMed PMID: 9142505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity to the motoric effects of a dopamine receptor antagonist differs as a function of age at the time of dopamine depletion. AU - Sandstrom,M I, AU - Bruno,J P, PY - 1997/5/1/pubmed PY - 2000/6/20/medline PY - 1997/5/1/entrez SP - 293 EP - 300 JF - Developmental psychobiology JO - Dev Psychobiol VL - 30 IS - 4 N2 - The ability of the mixed D1/D2 dopamine (DA) receptor antagonist cis-flupentixol to impair locomotor behavior in adult rats depleted of DA as weanlings was determined. Rats received lateral ventricular injections of 6-hydroxydopamine (100-200 micrograms/hemisphere) or its vehicle solution on postnatal Day 20, 27, or 35. We compared the ability of cis-flupentixol (.06, .25, and 1.0 mg/kg. i.p.) to impair the initiation of voluntary locomotion (i.e., akinesia) in control and DA-depleted subjects. Despite the fact that analyses of tissue homogenates revealed comparably large (93-96%) depletions of striatal DA across the three ages, the lesioned animals differed markedly in their sensitivity to the behavioral effects of the receptor antagonist. Surprisingly, rats depleted of DA on Day 20 or 27 were no more sensitive than vehicle-treated controls to the akinesia-inducing effects of each dose of flupentixol. In contrast, rats depleted of DA on Day 35 were supersensitive to the effects of the drug as they exhibited akinesia after a low dose of flupentixol that had no effect in any controls or animals depleted of DA at younger ages. These results suggest clear age-dependent differences in the plasticity of residual striatal DA neurons following subtotal damage. SN - 0012-1630 UR - https://www.unboundmedicine.com/medline/citation/9142505/Sensitivity_to_the_motoric_effects_of_a_dopamine_receptor_antagonist_differs_as_a_function_of_age_at_the_time_of_dopamine_depletion_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -