Tags

Type your tag names separated by a space and hit enter

Nursery outbreak of neonatal fungal arthritis treated with fluconazole.
J Trop Pediatr. 1997 04; 43(2):106-8.JT

Abstract

Eight preterm infants with mean gestational age of 31.6 +/- 1.16 weeks and a mean birth weight of 1310 +/- 201.7 g presented at a mean postnatal age of 26 +/- 11.4 days with knee joint swellings and pedal oedema. There was no other clinical, haematological or microbiological evidence of bacterial sepsis. Fungal cultures yielded growth of Candida spp. from blood in five, from urine in four, from cerebrospinal fluid in one, and from all the three babies in whom the joints were aspirated. Radiographic changes of metaphysitis of the involved joints were noted in all. All infants had received prior antibiotic therapy. No infant had received total parenteral nutrition or had central lines inserted. All infants were treated with fluconazole in doses of 7.5 mg/kg/day for 6 weeks. Six of eight were thriving well at 3 months of age without any evidence of residual joint disease. One infant succumbed to disseminated disease and one was lost to follow-up. Candidial arthritis is an uncommon presentation of neonatal candidiasis. Fluconazole therapy proved effective.

Authors+Show Affiliations

Division of Neonatology, Nowrosjee Wadia Maternity Hospital, Parel, Bombay, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9143182

Citation

Merchant, R H., et al. "Nursery Outbreak of Neonatal Fungal Arthritis Treated With Fluconazole." Journal of Tropical Pediatrics, vol. 43, no. 2, 1997, pp. 106-8.
Merchant RH, Sanghvi KP, Sridhar N, et al. Nursery outbreak of neonatal fungal arthritis treated with fluconazole. J Trop Pediatr. 1997;43(2):106-8.
Merchant, R. H., Sanghvi, K. P., Sridhar, N., Sonigara, S., Mehta, K. P., & Joshi, N. C. (1997). Nursery outbreak of neonatal fungal arthritis treated with fluconazole. Journal of Tropical Pediatrics, 43(2), 106-8. https://doi.org/10.1093/tropej/43.2.106
Merchant RH, et al. Nursery Outbreak of Neonatal Fungal Arthritis Treated With Fluconazole. J Trop Pediatr. 1997;43(2):106-8. PubMed PMID: 9143182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nursery outbreak of neonatal fungal arthritis treated with fluconazole. AU - Merchant,R H, AU - Sanghvi,K P, AU - Sridhar,N, AU - Sonigara,S, AU - Mehta,K P, AU - Joshi,N C, PY - 1997/4/1/pubmed PY - 2000/5/12/medline PY - 1997/4/1/entrez SP - 106 EP - 8 JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. VL - 43 IS - 2 N2 - Eight preterm infants with mean gestational age of 31.6 +/- 1.16 weeks and a mean birth weight of 1310 +/- 201.7 g presented at a mean postnatal age of 26 +/- 11.4 days with knee joint swellings and pedal oedema. There was no other clinical, haematological or microbiological evidence of bacterial sepsis. Fungal cultures yielded growth of Candida spp. from blood in five, from urine in four, from cerebrospinal fluid in one, and from all the three babies in whom the joints were aspirated. Radiographic changes of metaphysitis of the involved joints were noted in all. All infants had received prior antibiotic therapy. No infant had received total parenteral nutrition or had central lines inserted. All infants were treated with fluconazole in doses of 7.5 mg/kg/day for 6 weeks. Six of eight were thriving well at 3 months of age without any evidence of residual joint disease. One infant succumbed to disseminated disease and one was lost to follow-up. Candidial arthritis is an uncommon presentation of neonatal candidiasis. Fluconazole therapy proved effective. SN - 0142-6338 UR - https://www.unboundmedicine.com/medline/citation/9143182/Nursery_outbreak_of_neonatal_fungal_arthritis_treated_with_fluconazole L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/43.2.106 DB - PRIME DP - Unbound Medicine ER -