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Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis.
Antimicrob Agents Chemother 1997; 41(5):893-7AA

Abstract

Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquinolone with potent activity against Toxoplasma gondii, was examined for potential synergistic activity when combined with other drugs used for treatment of human toxoplasmosis. Combinations of trovafloxacin with clarithromycin, pyrimethamine, or sulfadiazine demonstrated significantly enhanced activities compared to those observed with each drug alone. Our results suggest that combinations of trovafloxacin and other anti-toxoplasma drugs should be further explored for treatment of toxoplasmosis in humans.

Authors+Show Affiliations

Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California 94301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9145840

Citation

Khan, A A., et al. "Activity of Trovafloxacin in Combination With Other Drugs for Treatment of Acute Murine Toxoplasmosis." Antimicrobial Agents and Chemotherapy, vol. 41, no. 5, 1997, pp. 893-7.
Khan AA, Slifer T, Araujo FG, et al. Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. Antimicrob Agents Chemother. 1997;41(5):893-7.
Khan, A. A., Slifer, T., Araujo, F. G., Polzer, R. J., & Remington, J. S. (1997). Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. Antimicrobial Agents and Chemotherapy, 41(5), pp. 893-7.
Khan AA, et al. Activity of Trovafloxacin in Combination With Other Drugs for Treatment of Acute Murine Toxoplasmosis. Antimicrob Agents Chemother. 1997;41(5):893-7. PubMed PMID: 9145840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. AU - Khan,A A, AU - Slifer,T, AU - Araujo,F G, AU - Polzer,R J, AU - Remington,J S, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 893 EP - 7 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 41 IS - 5 N2 - Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquinolone with potent activity against Toxoplasma gondii, was examined for potential synergistic activity when combined with other drugs used for treatment of human toxoplasmosis. Combinations of trovafloxacin with clarithromycin, pyrimethamine, or sulfadiazine demonstrated significantly enhanced activities compared to those observed with each drug alone. Our results suggest that combinations of trovafloxacin and other anti-toxoplasma drugs should be further explored for treatment of toxoplasmosis in humans. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/9145840/Activity_of_trovafloxacin_in_combination_with_other_drugs_for_treatment_of_acute_murine_toxoplasmosis_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=9145840 DB - PRIME DP - Unbound Medicine ER -