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Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
Antimicrob Agents Chemother 1997; 41(5):1134-6AA

Abstract

The sequence of the trimethoprim resistance gene of the 3.7-kb plasmid (pIP823) that confers high-level resistance (MIC, 1,024 microg/ml) to Listeria monocytogenes BM4293 was determined. The gene was identical to dfrD recently detected in Staphylococcus haemolyticus MUR313. The corresponding protein, S2DHFR, represents the second class of high-level trimethoprim-resistant dihydrofolate reductase identified in gram-positive bacteria. We propose that trimethoprim resistance in L. monocytogenes BM4293 could originate in staphylococci.

Authors+Show Affiliations

Unité des Agents Antibactériens, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9145882

Citation

Charpentier, E, and P Courvalin. "Emergence of the Trimethoprim Resistance Gene dfrD in Listeria Monocytogenes BM4293." Antimicrobial Agents and Chemotherapy, vol. 41, no. 5, 1997, pp. 1134-6.
Charpentier E, Courvalin P. Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293. Antimicrob Agents Chemother. 1997;41(5):1134-6.
Charpentier, E., & Courvalin, P. (1997). Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293. Antimicrobial Agents and Chemotherapy, 41(5), pp. 1134-6.
Charpentier E, Courvalin P. Emergence of the Trimethoprim Resistance Gene dfrD in Listeria Monocytogenes BM4293. Antimicrob Agents Chemother. 1997;41(5):1134-6. PubMed PMID: 9145882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293. AU - Charpentier,E, AU - Courvalin,P, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 1134 EP - 6 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 41 IS - 5 N2 - The sequence of the trimethoprim resistance gene of the 3.7-kb plasmid (pIP823) that confers high-level resistance (MIC, 1,024 microg/ml) to Listeria monocytogenes BM4293 was determined. The gene was identical to dfrD recently detected in Staphylococcus haemolyticus MUR313. The corresponding protein, S2DHFR, represents the second class of high-level trimethoprim-resistant dihydrofolate reductase identified in gram-positive bacteria. We propose that trimethoprim resistance in L. monocytogenes BM4293 could originate in staphylococci. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/9145882/Emergence_of_the_trimethoprim_resistance_gene_dfrD_in_Listeria_monocytogenes_BM4293_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=9145882 DB - PRIME DP - Unbound Medicine ER -