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Comparative effects of recombinant ovine placental lactogen and bovine growth hormone on galactopoiesis in ewes.
J Dairy Sci 1997; 80(4):640-5JD

Abstract

The effects of recombinant ovine placental lactogen and bovine growth hormone on milk yield, milk composition, and concentrations of blood hormones and metabolites were compared in ewes during an established lactation. Beginning on d 17 of lactation, ewes were treated for 5 d with twice daily subcutaneous injections of ovine placental lactogen (n = 9), bovine growth hormone (n = 10) at a dose of 0.10 mg/d per kg of body weight, or saline (n = 10). Circulating concentrations of ovine placental lactogen were 24.6 +/- 1.6 ng/ml on d 5 for ewes treated with ovine placental lactogen, but concentrations of ovine placental lactogen were undetectable in ewes treated with either saline or bovine growth hormone. Treatment with bovine growth hormone increased circulating concentrations of growth hormone, insulin-like growth factor-I, and nonesterified fatty acids and decreased urea concentrations relative to those in ewes treated with ovine placental lactogen or saline. Compared with saline treatment, no parameters were affected by treatment with ovine placental lactogen. Treatment with bovine growth hormone or ovine placental lactogen treatment had no significant effects on plasma concentrations of insulin, glucose, or creatinine. Treatment with bovine growth hormone, but not ovine placental lactogen, increased yields of milk, fat, and lactose. Weight of the mammary gland was increased by bovine growth hormone, but not by ovine placental lactogen. Despite the fact that ovine placental lactogen is a potent somatogen, it does not appear to exhibit the same galactopoietic activity as bovine growth hormone in lactating ewes.

Authors+Show Affiliations

Department of Animal Science, Massey University, Palmerston North, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9149958

Citation

Min, S H., et al. "Comparative Effects of Recombinant Ovine Placental Lactogen and Bovine Growth Hormone On Galactopoiesis in Ewes." Journal of Dairy Science, vol. 80, no. 4, 1997, pp. 640-5.
Min SH, Mackenzie DD, McCutcheon SN, et al. Comparative effects of recombinant ovine placental lactogen and bovine growth hormone on galactopoiesis in ewes. J Dairy Sci. 1997;80(4):640-5.
Min, S. H., Mackenzie, D. D., McCutcheon, S. N., Breier, B. H., & Gluckman, P. D. (1997). Comparative effects of recombinant ovine placental lactogen and bovine growth hormone on galactopoiesis in ewes. Journal of Dairy Science, 80(4), pp. 640-5.
Min SH, et al. Comparative Effects of Recombinant Ovine Placental Lactogen and Bovine Growth Hormone On Galactopoiesis in Ewes. J Dairy Sci. 1997;80(4):640-5. PubMed PMID: 9149958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of recombinant ovine placental lactogen and bovine growth hormone on galactopoiesis in ewes. AU - Min,S H, AU - Mackenzie,D D, AU - McCutcheon,S N, AU - Breier,B H, AU - Gluckman,P D, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 640 EP - 5 JF - Journal of dairy science JO - J. Dairy Sci. VL - 80 IS - 4 N2 - The effects of recombinant ovine placental lactogen and bovine growth hormone on milk yield, milk composition, and concentrations of blood hormones and metabolites were compared in ewes during an established lactation. Beginning on d 17 of lactation, ewes were treated for 5 d with twice daily subcutaneous injections of ovine placental lactogen (n = 9), bovine growth hormone (n = 10) at a dose of 0.10 mg/d per kg of body weight, or saline (n = 10). Circulating concentrations of ovine placental lactogen were 24.6 +/- 1.6 ng/ml on d 5 for ewes treated with ovine placental lactogen, but concentrations of ovine placental lactogen were undetectable in ewes treated with either saline or bovine growth hormone. Treatment with bovine growth hormone increased circulating concentrations of growth hormone, insulin-like growth factor-I, and nonesterified fatty acids and decreased urea concentrations relative to those in ewes treated with ovine placental lactogen or saline. Compared with saline treatment, no parameters were affected by treatment with ovine placental lactogen. Treatment with bovine growth hormone or ovine placental lactogen treatment had no significant effects on plasma concentrations of insulin, glucose, or creatinine. Treatment with bovine growth hormone, but not ovine placental lactogen, increased yields of milk, fat, and lactose. Weight of the mammary gland was increased by bovine growth hormone, but not by ovine placental lactogen. Despite the fact that ovine placental lactogen is a potent somatogen, it does not appear to exhibit the same galactopoietic activity as bovine growth hormone in lactating ewes. SN - 0022-0302 UR - https://www.unboundmedicine.com/medline/citation/9149958/Comparative_effects_of_recombinant_ovine_placental_lactogen_and_bovine_growth_hormone_on_galactopoiesis_in_ewes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(97)75982-4 DB - PRIME DP - Unbound Medicine ER -