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HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy.
J Rheumatol. 1997 May; 24(5):904-7.JR

Abstract

OBJECTIVE

HLA class II encoded factors may influence the phenotype of ankylosing spondylitis (AS). These include HLA DRB1*07 for peripheral arthritis, and polymorphism of the HLA-linked LMP2 locus and HLA DRB1*08 for acute anterior uveitis (AAU). We studied the relationship between DRB1*08 and disease phenotype in additional populations of individuals with AS.

METHODS

The patient population included 385 unrelated HLA-B27 positive individuals with AS. These included 204 Caucasians and 2 populations of Mexican Mestizo with AS: 106 with predominately adult onset disease from Guadalajara and 75 with predominately juvenile onset disease from Mexico City. The control population of 428 individuals included 210 random and 36 HLA-B27 positive unrelated Canadian Caucasians and 173 random and 9 HLA-B27 positive Mexican Mestizo from Mexico City. DRB1*08 typing was by sequence specific polymerase chain reaction.

RESULTS

A significantly higher prevalence of DRB1*08 was observed in Mexican patients with juvenile onset disease (44.9%) and especially those with undifferentiated spondyloarthropathy (55.6%) compared to normal unrelated Mexican Mestizo (25.4%) (p < 0.01 for both) and in patients with undifferentiated spondyloarthropathy versus B27 controls (11.1%) (p = 0.03), although no significant differences were observed in within patient group comparisons based on phenotypic features of disease such as AAU and age at onset. No significant relationship between DRB1*08 and disease phenotype was evident in Caucasian individuals.

CONCLUSION

Our data suggest DRB1*08 may influence the phenotype of spondyloarthritis in Mexican Mestizo, but do not support the view that DRB1*08 influences the development of AAU, as reported in a Japanese population.

Authors+Show Affiliations

Department of Medicine, University of Alberta, Edmonton, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9150079

Citation

Maksymowych, W P., et al. "HLA-DRB1*08 Influences the Development of Disease in Mexican Mestizo With Spondyloarthropathy." The Journal of Rheumatology, vol. 24, no. 5, 1997, pp. 904-7.
Maksymowych WP, Gorodezky C, Olivo A, et al. HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy. J Rheumatol. 1997;24(5):904-7.
Maksymowych, W. P., Gorodezky, C., Olivo, A., Alaez, C., Wong, C., Burgos-Vargas, R., Sanchez-Corona, J., Ramos-Remus, C., & Russell, A. S. (1997). HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy. The Journal of Rheumatology, 24(5), 904-7.
Maksymowych WP, et al. HLA-DRB1*08 Influences the Development of Disease in Mexican Mestizo With Spondyloarthropathy. J Rheumatol. 1997;24(5):904-7. PubMed PMID: 9150079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy. AU - Maksymowych,W P, AU - Gorodezky,C, AU - Olivo,A, AU - Alaez,C, AU - Wong,C, AU - Burgos-Vargas,R, AU - Sanchez-Corona,J, AU - Ramos-Remus,C, AU - Russell,A S, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 904 EP - 7 JF - The Journal of rheumatology JO - J Rheumatol VL - 24 IS - 5 N2 - OBJECTIVE: HLA class II encoded factors may influence the phenotype of ankylosing spondylitis (AS). These include HLA DRB1*07 for peripheral arthritis, and polymorphism of the HLA-linked LMP2 locus and HLA DRB1*08 for acute anterior uveitis (AAU). We studied the relationship between DRB1*08 and disease phenotype in additional populations of individuals with AS. METHODS: The patient population included 385 unrelated HLA-B27 positive individuals with AS. These included 204 Caucasians and 2 populations of Mexican Mestizo with AS: 106 with predominately adult onset disease from Guadalajara and 75 with predominately juvenile onset disease from Mexico City. The control population of 428 individuals included 210 random and 36 HLA-B27 positive unrelated Canadian Caucasians and 173 random and 9 HLA-B27 positive Mexican Mestizo from Mexico City. DRB1*08 typing was by sequence specific polymerase chain reaction. RESULTS: A significantly higher prevalence of DRB1*08 was observed in Mexican patients with juvenile onset disease (44.9%) and especially those with undifferentiated spondyloarthropathy (55.6%) compared to normal unrelated Mexican Mestizo (25.4%) (p < 0.01 for both) and in patients with undifferentiated spondyloarthropathy versus B27 controls (11.1%) (p = 0.03), although no significant differences were observed in within patient group comparisons based on phenotypic features of disease such as AAU and age at onset. No significant relationship between DRB1*08 and disease phenotype was evident in Caucasian individuals. CONCLUSION: Our data suggest DRB1*08 may influence the phenotype of spondyloarthritis in Mexican Mestizo, but do not support the view that DRB1*08 influences the development of AAU, as reported in a Japanese population. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9150079/HLA_DRB1_08_influences_the_development_of_disease_in_Mexican_Mestizo_with_spondyloarthropathy_ DB - PRIME DP - Unbound Medicine ER -