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Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study.

Abstract

The hippocampus, parietal cortex, and insula were measured on volumetric magnetic resonance imaging to determine whether patients with early Alzheimer's disease had significantly more atrophy than healthy controls. To determine whether the atrophy is limited to certain cortical regions, the striate cortex was measured because this area is not usually neuropathologically involved early in Alzheimer's disease. Eight mildly to moderately impaired patients who met National Institute of Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable Alzheimer's disease and eight controls who matched for age, gender, and educational level were studied. Atrophy was quantified in the following regions: hippocampus, parietal cortex, insular cortex, and striate cortex. The authors found significantly more atrophy of the hippocampus (p < 0.0001), parietal cortex (p < 0.025), and insula (p < 0.003) in the Alzheimer's patients. Measures of the striate cortex did not differ between the groups. There were no significant left-right differences in any of the regions measured. Their findings show that mildly to moderately impaired Alzheimer's patients have significantly more atrophy of the hippocampus, parietal cortex, and insula than healthy age-matched controls. Furthermore, this atrophy is probably discrete because the groups did not differ on measures of the striate cortex. Selective atrophy of the parietal and insular cortices has not previously been reported using the authors' methodology on volumetric magnetic resonance imaging. Their data suggest that the insula may be involved early in Alzheimer's disease and that atrophy of the insular cortex may contribute to the cognitive deficits typical of early Alzheimer's disease.

Authors+Show Affiliations

Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, Louisiana 70112-2632, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9150507

Citation

Foundas, A L., et al. "Atrophy of the Hippocampus, Parietal Cortex, and Insula in Alzheimer's Disease: a Volumetric Magnetic Resonance Imaging Study." Neuropsychiatry, Neuropsychology, and Behavioral Neurology, vol. 10, no. 2, 1997, pp. 81-9.
Foundas AL, Leonard CM, Mahoney SM, et al. Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study. Neuropsychiatry Neuropsychol Behav Neurol. 1997;10(2):81-9.
Foundas, A. L., Leonard, C. M., Mahoney, S. M., Agee, O. F., & Heilman, K. M. (1997). Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 10(2), pp. 81-9.
Foundas AL, et al. Atrophy of the Hippocampus, Parietal Cortex, and Insula in Alzheimer's Disease: a Volumetric Magnetic Resonance Imaging Study. Neuropsychiatry Neuropsychol Behav Neurol. 1997;10(2):81-9. PubMed PMID: 9150507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study. AU - Foundas,A L, AU - Leonard,C M, AU - Mahoney,S M, AU - Agee,O F, AU - Heilman,K M, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 81 EP - 9 JF - Neuropsychiatry, neuropsychology, and behavioral neurology JO - Neuropsychiatry Neuropsychol Behav Neurol VL - 10 IS - 2 N2 - The hippocampus, parietal cortex, and insula were measured on volumetric magnetic resonance imaging to determine whether patients with early Alzheimer's disease had significantly more atrophy than healthy controls. To determine whether the atrophy is limited to certain cortical regions, the striate cortex was measured because this area is not usually neuropathologically involved early in Alzheimer's disease. Eight mildly to moderately impaired patients who met National Institute of Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable Alzheimer's disease and eight controls who matched for age, gender, and educational level were studied. Atrophy was quantified in the following regions: hippocampus, parietal cortex, insular cortex, and striate cortex. The authors found significantly more atrophy of the hippocampus (p < 0.0001), parietal cortex (p < 0.025), and insula (p < 0.003) in the Alzheimer's patients. Measures of the striate cortex did not differ between the groups. There were no significant left-right differences in any of the regions measured. Their findings show that mildly to moderately impaired Alzheimer's patients have significantly more atrophy of the hippocampus, parietal cortex, and insula than healthy age-matched controls. Furthermore, this atrophy is probably discrete because the groups did not differ on measures of the striate cortex. Selective atrophy of the parietal and insular cortices has not previously been reported using the authors' methodology on volumetric magnetic resonance imaging. Their data suggest that the insula may be involved early in Alzheimer's disease and that atrophy of the insular cortex may contribute to the cognitive deficits typical of early Alzheimer's disease. SN - 0894-878X UR - https://www.unboundmedicine.com/medline/citation/9150507/Atrophy_of_the_hippocampus_parietal_cortex_and_insula_in_Alzheimer's_disease:_a_volumetric_magnetic_resonance_imaging_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9150507.ui DB - PRIME DP - Unbound Medicine ER -