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Intraepithelial lymphocytes bearing the gamma/delta receptor in the oral and jejunal mucosa in patients with dermatitis herpetiformis.
Eur J Oral Sci. 1997 Apr; 105(2):130-5.EJ

Abstract

Lymphocytes bearing T cell receptor (TcR) gamma/delta are increased in the jejunal mucosa of patients with dermatitis herpetiformis (DH) and coeliac disease. In this study, we examined whether increased numbers of gamma/delta TcR positive lymphocytes occur in the oral mucosa of patients with DH. Oral and jejunal mucosal biopsies were taken from 13 newly diagnosed and 13 gluten free diet (GFD)-treated patients with DH. Monoclonal antibodies and avidin-biotin peroxidase method was used for staining, and TcR positive cells were counted from the buccal and jejunal epithelium. Very few gamma/delta TcR positive lymphocytes were seen in the buccal epithelium of untreated or GFD-treated DH patients (median 0.4 and 0.3 cells/mm2), whereas alpha/beta TcR positive lymphocytes were frequent in both groups of DH patients (154 and 250 cells/mm2) and healthy controls (135 cells/mm2). The numbers of gamma/delta TcR positive intraepithelial lymphocytes were significantly increased in the jejunum of both untreated (43 cells/mm) and GFD-treated (27 cells/mm) DH patients compared to control patients (2.2 cells/mm). The present study did not, therefore, disclose any evidence for active recruitment of gamma/delta TcR positive lymphocytes in the oral epithelium, but showed substantial amounts of intraepithelial alpha/beta TcR positive lymphocytes both in DH patients and healthy controls.

Authors+Show Affiliations

Department of Oral Medicine, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9151065

Citation

Patinen, P, et al. "Intraepithelial Lymphocytes Bearing the Gamma/delta Receptor in the Oral and Jejunal Mucosa in Patients With Dermatitis Herpetiformis." European Journal of Oral Sciences, vol. 105, no. 2, 1997, pp. 130-5.
Patinen P, Savilahti E, Hietanen J, et al. Intraepithelial lymphocytes bearing the gamma/delta receptor in the oral and jejunal mucosa in patients with dermatitis herpetiformis. Eur J Oral Sci. 1997;105(2):130-5.
Patinen, P., Savilahti, E., Hietanen, J., Malmström, M., Mäki, M., & Reunala, T. (1997). Intraepithelial lymphocytes bearing the gamma/delta receptor in the oral and jejunal mucosa in patients with dermatitis herpetiformis. European Journal of Oral Sciences, 105(2), 130-5.
Patinen P, et al. Intraepithelial Lymphocytes Bearing the Gamma/delta Receptor in the Oral and Jejunal Mucosa in Patients With Dermatitis Herpetiformis. Eur J Oral Sci. 1997;105(2):130-5. PubMed PMID: 9151065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraepithelial lymphocytes bearing the gamma/delta receptor in the oral and jejunal mucosa in patients with dermatitis herpetiformis. AU - Patinen,P, AU - Savilahti,E, AU - Hietanen,J, AU - Malmström,M, AU - Mäki,M, AU - Reunala,T, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 130 EP - 5 JF - European journal of oral sciences JO - Eur J Oral Sci VL - 105 IS - 2 N2 - Lymphocytes bearing T cell receptor (TcR) gamma/delta are increased in the jejunal mucosa of patients with dermatitis herpetiformis (DH) and coeliac disease. In this study, we examined whether increased numbers of gamma/delta TcR positive lymphocytes occur in the oral mucosa of patients with DH. Oral and jejunal mucosal biopsies were taken from 13 newly diagnosed and 13 gluten free diet (GFD)-treated patients with DH. Monoclonal antibodies and avidin-biotin peroxidase method was used for staining, and TcR positive cells were counted from the buccal and jejunal epithelium. Very few gamma/delta TcR positive lymphocytes were seen in the buccal epithelium of untreated or GFD-treated DH patients (median 0.4 and 0.3 cells/mm2), whereas alpha/beta TcR positive lymphocytes were frequent in both groups of DH patients (154 and 250 cells/mm2) and healthy controls (135 cells/mm2). The numbers of gamma/delta TcR positive intraepithelial lymphocytes were significantly increased in the jejunum of both untreated (43 cells/mm) and GFD-treated (27 cells/mm) DH patients compared to control patients (2.2 cells/mm). The present study did not, therefore, disclose any evidence for active recruitment of gamma/delta TcR positive lymphocytes in the oral epithelium, but showed substantial amounts of intraepithelial alpha/beta TcR positive lymphocytes both in DH patients and healthy controls. SN - 0909-8836 UR - https://www.unboundmedicine.com/medline/citation/9151065/Intraepithelial_lymphocytes_bearing_the_gamma/delta_receptor_in_the_oral_and_jejunal_mucosa_in_patients_with_dermatitis_herpetiformis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0909-8836&date=1997&volume=105&issue=2&spage=130 DB - PRIME DP - Unbound Medicine ER -