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Pernicious anaemia patients should be screened for iron deficiency during follow up.
N Z Med J 1997; 110(1042):147-8NZ

Abstract

AIMS

To investigate if patients with pernicious anaemia (PA) are prone to develop iron deficiency and if there is a difference for this manifestation between younger and older age groups.

METHODS

Ninety-five patients with pernicious anaemia were evaluated for body iron status at the time of diagnosis and during follow up. Patients were also divided into two groups; younger than 60 (53 patients) and older than 60 (42 patients) years of age. Groups were compared for iron deficiency both at the time of diagnosis and at the end of follow up period.

RESULTS

Iron deficiency was a common finding in patients with pernicious anaemia. This deficiency state was more common in the elderly. During B12 therapy, iron deficiency increased in all groups, but the increased rate of iron deficiency was more prominent in the elderly patients.

CONCLUSION

Pernicious anaemia is an atrophic gastropathy in which gastric parietal cells no longer produce hydrochloric acid. These patients with achlorhydria demonstrate impaired absorption of iron. On the other hand, with ageing, gastric acidity is already diminished. Iron deficiency commonly accompanies patients with pernicious anaemia and this is more pronounced in the elderly group. We suggest that all patients with pernicious anaemia, especially the elderly, should be screened for iron deficiency both at the beginning and during the follow up.

Authors+Show Affiliations

Department of Haematology, Hacettepe University Medical School, Ankara, Turkey.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

9152357

Citation

Demiroğlu, H, and S Dündar. "Pernicious Anaemia Patients Should Be Screened for Iron Deficiency During Follow Up." The New Zealand Medical Journal, vol. 110, no. 1042, 1997, pp. 147-8.
Demiroğlu H, Dündar S. Pernicious anaemia patients should be screened for iron deficiency during follow up. N Z Med J. 1997;110(1042):147-8.
Demiroğlu, H., & Dündar, S. (1997). Pernicious anaemia patients should be screened for iron deficiency during follow up. The New Zealand Medical Journal, 110(1042), pp. 147-8.
Demiroğlu H, Dündar S. Pernicious Anaemia Patients Should Be Screened for Iron Deficiency During Follow Up. N Z Med J. 1997 Apr 25;110(1042):147-8. PubMed PMID: 9152357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pernicious anaemia patients should be screened for iron deficiency during follow up. AU - Demiroğlu,H, AU - Dündar,S, PY - 1997/4/25/pubmed PY - 1997/4/25/medline PY - 1997/4/25/entrez SP - 147 EP - 8 JF - The New Zealand medical journal JO - N. Z. Med. J. VL - 110 IS - 1042 N2 - AIMS: To investigate if patients with pernicious anaemia (PA) are prone to develop iron deficiency and if there is a difference for this manifestation between younger and older age groups. METHODS: Ninety-five patients with pernicious anaemia were evaluated for body iron status at the time of diagnosis and during follow up. Patients were also divided into two groups; younger than 60 (53 patients) and older than 60 (42 patients) years of age. Groups were compared for iron deficiency both at the time of diagnosis and at the end of follow up period. RESULTS: Iron deficiency was a common finding in patients with pernicious anaemia. This deficiency state was more common in the elderly. During B12 therapy, iron deficiency increased in all groups, but the increased rate of iron deficiency was more prominent in the elderly patients. CONCLUSION: Pernicious anaemia is an atrophic gastropathy in which gastric parietal cells no longer produce hydrochloric acid. These patients with achlorhydria demonstrate impaired absorption of iron. On the other hand, with ageing, gastric acidity is already diminished. Iron deficiency commonly accompanies patients with pernicious anaemia and this is more pronounced in the elderly group. We suggest that all patients with pernicious anaemia, especially the elderly, should be screened for iron deficiency both at the beginning and during the follow up. SN - 0028-8446 UR - https://www.unboundmedicine.com/medline/citation/9152357/Pernicious_anaemia_patients_should_be_screened_for_iron_deficiency_during_follow_up_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -