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Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection.
Biol Trace Elem Res. 1997 Jan; 56(1):31-41.BT

Abstract

Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 micrograms/L; p < 0.01; n = 19) HIV-infected patients, than in healthy subjects (80.6 +/- 9.6 micrograms/L; n = 48) and stage I patients (73.6 +/- 16.5 micrograms/L; n = 20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r = 0.42; r = 0.39; r = 0.48; and r = 0.45; p < 0.01, respectively) and inversely with serum levels of thymidine kinase (r = -0.49; p < 0.01; n = 49) and beta 2-microglobulin (r = -0.46; p < 0.001; n = 49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I: n = 10; CDC II: n = 10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors (sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD(4+)-cells and with increased levels of markers of disease progression and inflammatory response.

Authors+Show Affiliations

Look MP
Department of General Internal Medicine, University of Bonn, Germany.
Rockstroh JK
No affiliation info available
Rao GS
No affiliation info available
Kreuzer KA
No affiliation info available
Spengler U
No affiliation info available
Sauerbruch T
No affiliation info available

MeSH

AdultBiomarkersCD4 Lymphocyte CountCD4-CD8 RatioCase-Control StudiesFemaleHIV InfectionsHIV-1HumansInflammationInterleukin-8MaleMiddle AgedReceptors, Tumor Necrosis FactorSeleniumThymidine Kinasebeta 2-Microglobulin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9152510

Citation

Look, M P., et al. "Serum Selenium Versus Lymphocyte Subsets and Markers of Disease Progression and Inflammatory Response in Human Immunodeficiency Virus-1 Infection." Biological Trace Element Research, vol. 56, no. 1, 1997, pp. 31-41.
Look MP, Rockstroh JK, Rao GS, et al. Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection. Biol Trace Elem Res. 1997;56(1):31-41.
Look, M. P., Rockstroh, J. K., Rao, G. S., Kreuzer, K. A., Spengler, U., & Sauerbruch, T. (1997). Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection. Biological Trace Element Research, 56(1), 31-41.
Look MP, et al. Serum Selenium Versus Lymphocyte Subsets and Markers of Disease Progression and Inflammatory Response in Human Immunodeficiency Virus-1 Infection. Biol Trace Elem Res. 1997;56(1):31-41. PubMed PMID: 9152510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection. AU - Look,M P, AU - Rockstroh,J K, AU - Rao,G S, AU - Kreuzer,K A, AU - Spengler,U, AU - Sauerbruch,T, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 31 EP - 41 JF - Biological trace element research JO - Biol Trace Elem Res VL - 56 IS - 1 N2 - Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 micrograms/L; p < 0.01; n = 19) HIV-infected patients, than in healthy subjects (80.6 +/- 9.6 micrograms/L; n = 48) and stage I patients (73.6 +/- 16.5 micrograms/L; n = 20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r = 0.42; r = 0.39; r = 0.48; and r = 0.45; p < 0.01, respectively) and inversely with serum levels of thymidine kinase (r = -0.49; p < 0.01; n = 49) and beta 2-microglobulin (r = -0.46; p < 0.001; n = 49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I: n = 10; CDC II: n = 10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors (sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD(4+)-cells and with increased levels of markers of disease progression and inflammatory response. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/9152510/Serum_selenium_versus_lymphocyte_subsets_and_markers_of_disease_progression_and_inflammatory_response_in_human_immunodeficiency_virus_1_infection_ L2 - https://dx.doi.org/10.1007/BF02778982 DB - PRIME DP - Unbound Medicine ER -