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Associations of adiposity with prevalent coronary heart disease among elderly men: the Honolulu Heart Program.
Int J Obes Relat Metab Disord. 1997 May; 21(5):340-8.IJ

Abstract

OBJECTIVE

To assess associations of adiposity with prevalent coronary heart disease (CHD) among elderly men.

DESIGN

A cross-sectional epidemiologic study conducted between 1991 and 1993.

SUBJECTS

3741 Japanese-American men from the Honolulu Heart Program who were 71-93 y of age.

MEASUREMENTS

CHD included documented myocardial infarction (electrocardiographic and enzyme criteria), acute coronary insufficiency, angina pectoris leading to surgical treatment identified through hospital surveillance, and reported history of heart attach or angina pectoris requiring hospitalization or surgical treatment. BMI was calculated as weight in kg divided by height in square meters. Waist circumference was measured at the horizontal level of the umbilicus and WHR was a ratio of waist circumference to hip circumference measured at the horizontal level of the maximal protrusion of the gluteal muscles.

RESULTS

An elevated prevalence of CHD was observed in the elderly men with high BMI, WHR and waist circumference. The significant associations of BMI and waist circumference with CHD persisted after adjustment for fasting glucose, physical activity and pack-years of cigarette smoking but were no longer significant (odds ration (OR) = 1.03, 95% confidence level (CI) 0.94-1.12 and OR = 1.09, CI = 0.99-1.20, respectively) after adjustment for high density lipoprotein cholesterol (HDL-C). Also, the association of BMI with CHD was not found to be independent of abdominal adiposity. However, the associations of WHR and waist circumference remained significant (OR = 1.20, CI = 1.08-1.33 and OR = 1.17, CI = 1.01-1.37, respectively) after additional adjustment for BMI. In addition, the association of WHR with CHD was consistently significant and independent of fasting glucose, physical activity, smoking and HDL-C (OR = 1.11, CI = 1.00-1.23).

CONCLUSION

WHR is associated with CHD independent of HDL-C and BMI, whereas the relation of BMI and waist circumference with CHD may be mediated through a relation of BMI and waist circumference with HDL-C level.

Authors+Show Affiliations

Honolulu Heart Program, Research Corporation of the University of Hawaii, Division of Clinical Epidemiology, School of Medicine 96817, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9152734

Citation

Huang, B, et al. "Associations of Adiposity With Prevalent Coronary Heart Disease Among Elderly Men: the Honolulu Heart Program." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 21, no. 5, 1997, pp. 340-8.
Huang B, Rodreiguez BL, Burchfiel CM, et al. Associations of adiposity with prevalent coronary heart disease among elderly men: the Honolulu Heart Program. Int J Obes Relat Metab Disord. 1997;21(5):340-8.
Huang, B., Rodreiguez, B. L., Burchfiel, C. M., Chyou, P. H., Curb, J. D., & Sharp, D. S. (1997). Associations of adiposity with prevalent coronary heart disease among elderly men: the Honolulu Heart Program. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 21(5), 340-8.
Huang B, et al. Associations of Adiposity With Prevalent Coronary Heart Disease Among Elderly Men: the Honolulu Heart Program. Int J Obes Relat Metab Disord. 1997;21(5):340-8. PubMed PMID: 9152734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of adiposity with prevalent coronary heart disease among elderly men: the Honolulu Heart Program. AU - Huang,B, AU - Rodreiguez,B L, AU - Burchfiel,C M, AU - Chyou,P H, AU - Curb,J D, AU - Sharp,D S, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 340 EP - 8 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int. J. Obes. Relat. Metab. Disord. VL - 21 IS - 5 N2 - OBJECTIVE: To assess associations of adiposity with prevalent coronary heart disease (CHD) among elderly men. DESIGN: A cross-sectional epidemiologic study conducted between 1991 and 1993. SUBJECTS: 3741 Japanese-American men from the Honolulu Heart Program who were 71-93 y of age. MEASUREMENTS: CHD included documented myocardial infarction (electrocardiographic and enzyme criteria), acute coronary insufficiency, angina pectoris leading to surgical treatment identified through hospital surveillance, and reported history of heart attach or angina pectoris requiring hospitalization or surgical treatment. BMI was calculated as weight in kg divided by height in square meters. Waist circumference was measured at the horizontal level of the umbilicus and WHR was a ratio of waist circumference to hip circumference measured at the horizontal level of the maximal protrusion of the gluteal muscles. RESULTS: An elevated prevalence of CHD was observed in the elderly men with high BMI, WHR and waist circumference. The significant associations of BMI and waist circumference with CHD persisted after adjustment for fasting glucose, physical activity and pack-years of cigarette smoking but were no longer significant (odds ration (OR) = 1.03, 95% confidence level (CI) 0.94-1.12 and OR = 1.09, CI = 0.99-1.20, respectively) after adjustment for high density lipoprotein cholesterol (HDL-C). Also, the association of BMI with CHD was not found to be independent of abdominal adiposity. However, the associations of WHR and waist circumference remained significant (OR = 1.20, CI = 1.08-1.33 and OR = 1.17, CI = 1.01-1.37, respectively) after additional adjustment for BMI. In addition, the association of WHR with CHD was consistently significant and independent of fasting glucose, physical activity, smoking and HDL-C (OR = 1.11, CI = 1.00-1.23). CONCLUSION: WHR is associated with CHD independent of HDL-C and BMI, whereas the relation of BMI and waist circumference with CHD may be mediated through a relation of BMI and waist circumference with HDL-C level. UR - https://www.unboundmedicine.com/medline/citation/9152734/Associations_of_adiposity_with_prevalent_coronary_heart_disease_among_elderly_men:_the_Honolulu_Heart_Program_ L2 - https://ClinicalTrials.gov/search/term=9152734 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -