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Adenosine triphosphate levels during anaphylactic histamine release in rat mast cells in vitro. Effects of glycolytic and respiratory inhibitors.
Eur J Pharmacol. 1979 Sep 15; 58(2):107-15.EJ

Abstract

The adenosine triphosphate (ATP) content of rat mast cells was studied during and after anaphylactic histamine release. The almost identical time course of ATP decrease from mast cells treated with either glycolytic or respiratory inhibitors supports the view that the ATP depletion was largely related to the histamine release process and not to an uncoupling of oxidative phosphorylation by an increased concentration of cytosol Ca2+. The ATP content of the cells was not restored within the 2 h of observation. No inhibition of lactate production from mast cells exposed to antigen in the presence of respiratory inhibitors and glucose was observed. Based on the lactate production from mast cells, the turnover time of ATP was calculated to be about 3/4 min.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

91528

Citation

Johansen, T. "Adenosine Triphosphate Levels During Anaphylactic Histamine Release in Rat Mast Cells in Vitro. Effects of Glycolytic and Respiratory Inhibitors." European Journal of Pharmacology, vol. 58, no. 2, 1979, pp. 107-15.
Johansen T. Adenosine triphosphate levels during anaphylactic histamine release in rat mast cells in vitro. Effects of glycolytic and respiratory inhibitors. Eur J Pharmacol. 1979;58(2):107-15.
Johansen, T. (1979). Adenosine triphosphate levels during anaphylactic histamine release in rat mast cells in vitro. Effects of glycolytic and respiratory inhibitors. European Journal of Pharmacology, 58(2), 107-15.
Johansen T. Adenosine Triphosphate Levels During Anaphylactic Histamine Release in Rat Mast Cells in Vitro. Effects of Glycolytic and Respiratory Inhibitors. Eur J Pharmacol. 1979 Sep 15;58(2):107-15. PubMed PMID: 91528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenosine triphosphate levels during anaphylactic histamine release in rat mast cells in vitro. Effects of glycolytic and respiratory inhibitors. A1 - Johansen,T, PY - 1979/9/15/pubmed PY - 1979/9/15/medline PY - 1979/9/15/entrez SP - 107 EP - 15 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 58 IS - 2 N2 - The adenosine triphosphate (ATP) content of rat mast cells was studied during and after anaphylactic histamine release. The almost identical time course of ATP decrease from mast cells treated with either glycolytic or respiratory inhibitors supports the view that the ATP depletion was largely related to the histamine release process and not to an uncoupling of oxidative phosphorylation by an increased concentration of cytosol Ca2+. The ATP content of the cells was not restored within the 2 h of observation. No inhibition of lactate production from mast cells exposed to antigen in the presence of respiratory inhibitors and glucose was observed. Based on the lactate production from mast cells, the turnover time of ATP was calculated to be about 3/4 min. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/91528/Adenosine_triphosphate_levels_during_anaphylactic_histamine_release_in_rat_mast_cells_in_vitro__Effects_of_glycolytic_and_respiratory_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(79)90001-3 DB - PRIME DP - Unbound Medicine ER -