Tags

Type your tag names separated by a space and hit enter

Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats.
Br J Nutr 1997; 77(4):645-56BJ

Abstract

To explore whether the metabolic responses to trans, compared with cis, fatty acids depend on the source of dietary polyunsaturated fatty acids (PUFA), male Sprague-Dawley rats, 5 weeks old, were fed on diets containing 30 g oleic (cis) or elaidic (trans) acids/kg in combination with either 70 g perilla oil (alpha-linolenic acid) or safflowerseed oil (linoleic acid)/kg for 3 weeks in separate experiments. The dietary fats were adjusted to have the same level of total PUFA. The dietary manipulation did not influence the growth indices, but spleen weight was greater when the dietary PUFA source was perilla oil. The incorporation of trans fatty acid into liver phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine and adipose tissue lipids, particularly phospholipids, was significantly higher when rats were fed on safflowerseed oil compared with perilla oil. However, only limited differences were observed in the effects of cis and trans fatty acids on the proportions of PUFA in liver phospholipids. Splenic production of prostaglandin E2 was reduced by trans fatty acid when safflowerseed oil was the PUFA source, but no trans effect was observed on leukotriene C4 production. Dietary PUFA significantly influenced the concentration of plasma immunoglobulins (Ig) but the effect of geometry was only seen in IgG which was increased by trans acid. Dietary trans fatty acid increased the CD4+:CD8+ T-lymphocyte ratio in the spleen, reflecting a decreasing trend of the proportion of CD8+, when combined with perilla oil. These observations indicate that the type of PUFA simultaneously ingested specifically influences the effect that trans acid exerts on PUFA metabolism, eicosanoid production and some immune indices.

Authors+Show Affiliations

Department of Food and Nutrition, Nakamura Gauen College, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9155511

Citation

Koga, T, et al. "Linoleic and Alpha-linolenic Acids Differently Modify the Effects of Elaidic Acid On Polyunsaturated Fatty Acid Metabolism and some Immune Indices in Rats." The British Journal of Nutrition, vol. 77, no. 4, 1997, pp. 645-56.
Koga T, Nonaka M, Gu JY, et al. Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. Br J Nutr. 1997;77(4):645-56.
Koga, T., Nonaka, M., Gu, J. Y., & Sugano, M. (1997). Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. The British Journal of Nutrition, 77(4), pp. 645-56.
Koga T, et al. Linoleic and Alpha-linolenic Acids Differently Modify the Effects of Elaidic Acid On Polyunsaturated Fatty Acid Metabolism and some Immune Indices in Rats. Br J Nutr. 1997;77(4):645-56. PubMed PMID: 9155511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. AU - Koga,T, AU - Nonaka,M, AU - Gu,J Y, AU - Sugano,M, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 645 EP - 56 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 77 IS - 4 N2 - To explore whether the metabolic responses to trans, compared with cis, fatty acids depend on the source of dietary polyunsaturated fatty acids (PUFA), male Sprague-Dawley rats, 5 weeks old, were fed on diets containing 30 g oleic (cis) or elaidic (trans) acids/kg in combination with either 70 g perilla oil (alpha-linolenic acid) or safflowerseed oil (linoleic acid)/kg for 3 weeks in separate experiments. The dietary fats were adjusted to have the same level of total PUFA. The dietary manipulation did not influence the growth indices, but spleen weight was greater when the dietary PUFA source was perilla oil. The incorporation of trans fatty acid into liver phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine and adipose tissue lipids, particularly phospholipids, was significantly higher when rats were fed on safflowerseed oil compared with perilla oil. However, only limited differences were observed in the effects of cis and trans fatty acids on the proportions of PUFA in liver phospholipids. Splenic production of prostaglandin E2 was reduced by trans fatty acid when safflowerseed oil was the PUFA source, but no trans effect was observed on leukotriene C4 production. Dietary PUFA significantly influenced the concentration of plasma immunoglobulins (Ig) but the effect of geometry was only seen in IgG which was increased by trans acid. Dietary trans fatty acid increased the CD4+:CD8+ T-lymphocyte ratio in the spleen, reflecting a decreasing trend of the proportion of CD8+, when combined with perilla oil. These observations indicate that the type of PUFA simultaneously ingested specifically influences the effect that trans acid exerts on PUFA metabolism, eicosanoid production and some immune indices. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9155511/Linoleic_and_alpha_linolenic_acids_differently_modify_the_effects_of_elaidic_acid_on_polyunsaturated_fatty_acid_metabolism_and_some_immune_indices_in_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114597000639/type/journal_article DB - PRIME DP - Unbound Medicine ER -