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Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.
Cancer Res. 1997 May 15; 57(10):1855-8.CR

Abstract

Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyzed loss of heterozygosity (LOH) in 188 tumors from 81 patients in an attempt to further define the location of the MEN1 gene. Both tumors from MEN1 patients and corresponding sporadic tumors were analyzed. Tumor types included parathyroid, gastrinoma, pancreatic endocrine, pituitary, and lung carcinoid. Six tumors (three MEN1 and three sporadic tumors) were identified that provided important LOH boundaries. Four tumors (two parathyroid tumors, one gastrinoma, and one lung carcinoid tumor) showed allelic loss that placed the MEN1 gene distal to marker PYGM. Two tumors (one gastrinoma and one parathyroid tumor) showed an LOH boundary that placed the gene proximal to D11S449, one of which further moved the telomeric boundary to D11S4936. Taken together, the present data suggest that the MEN1 gene lies between PYGM and D11S4936, a region of approximately 300 kb on chromosome 11q13.

Authors+Show Affiliations

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9157974

Citation

Emmert-Buck, M R., et al. "Localization of the Multiple Endocrine Neoplasia Type I (MEN1) Gene Based On Tumor Loss of Heterozygosity Analysis." Cancer Research, vol. 57, no. 10, 1997, pp. 1855-8.
Emmert-Buck MR, Lubensky IA, Dong Q, et al. Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Res. 1997;57(10):1855-8.
Emmert-Buck, M. R., Lubensky, I. A., Dong, Q., Manickam, P., Guru, S. C., Kester, M. B., Olufemi, S. E., Agarwal, S., Burns, A. L., Spiegel, A. M., Collins, F. S., Marx, S. J., Zhuang, Z., Liotta, L. A., Chandrasekharappa, S. C., & Debelenko, L. V. (1997). Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Research, 57(10), 1855-8.
Emmert-Buck MR, et al. Localization of the Multiple Endocrine Neoplasia Type I (MEN1) Gene Based On Tumor Loss of Heterozygosity Analysis. Cancer Res. 1997 May 15;57(10):1855-8. PubMed PMID: 9157974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. AU - Emmert-Buck,M R, AU - Lubensky,I A, AU - Dong,Q, AU - Manickam,P, AU - Guru,S C, AU - Kester,M B, AU - Olufemi,S E, AU - Agarwal,S, AU - Burns,A L, AU - Spiegel,A M, AU - Collins,F S, AU - Marx,S J, AU - Zhuang,Z, AU - Liotta,L A, AU - Chandrasekharappa,S C, AU - Debelenko,L V, PY - 1997/5/15/pubmed PY - 1997/5/15/medline PY - 1997/5/15/entrez SP - 1855 EP - 8 JF - Cancer research JO - Cancer Res VL - 57 IS - 10 N2 - Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyzed loss of heterozygosity (LOH) in 188 tumors from 81 patients in an attempt to further define the location of the MEN1 gene. Both tumors from MEN1 patients and corresponding sporadic tumors were analyzed. Tumor types included parathyroid, gastrinoma, pancreatic endocrine, pituitary, and lung carcinoid. Six tumors (three MEN1 and three sporadic tumors) were identified that provided important LOH boundaries. Four tumors (two parathyroid tumors, one gastrinoma, and one lung carcinoid tumor) showed allelic loss that placed the MEN1 gene distal to marker PYGM. Two tumors (one gastrinoma and one parathyroid tumor) showed an LOH boundary that placed the gene proximal to D11S449, one of which further moved the telomeric boundary to D11S4936. Taken together, the present data suggest that the MEN1 gene lies between PYGM and D11S4936, a region of approximately 300 kb on chromosome 11q13. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9157974/Localization_of_the_multiple_endocrine_neoplasia_type_I__MEN1__gene_based_on_tumor_loss_of_heterozygosity_analysis_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9157974 DB - PRIME DP - Unbound Medicine ER -