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An update on the discovery, pathophysiological actions, clinical manifestations and possible physiology of parathyroid related peptide.
P R Health Sci J. 1997 Mar; 16(1):15-22.PR

Abstract

PTHrP has had an unidentified role in medicine since 1930, when Albright described a patient with renal cortical cell carcinoma with hypercalcemia. Since then hypercalcemia has been recognized as the most common paraneoplastic syndrome. At that time the concept of "ectopic PTH syndrome" was introduced, and remained in literature until the true etiology was finally described. In the early 1970's Roof and Benson presented evidence that PTH in humoral hypercalcemia differed from "authentic" PTH. This marked the starting point for researchers to try identifying the molecule that mimicked PTH action and structure. This molecule, named parathyroid-related peptide, has been associated to hypercalcemia seen with solid tumors, such as squamous cell carcinoma of the lung and renal cortical cell carcinoma. PTHrP has been demonstrated to have similar actions to PTH but to differ in decreasing osteoblastic activity while increasing osteoclastic activity. The more fascinating finding was the presence of the PTHrP genes throughout the body, mostly the lactating breast as well as the heart, lungs and skin among others. Despite its identification, finding its physiological roles on normal tissue still remains to be clarified.

Authors+Show Affiliations

Alcantara A
Endocrinology Division, University of Puerto Rico Medical School, San Juan 00936-5067, USA.
Montalvo-Figueroa JA
No affiliation info available
Toro S
No affiliation info available
Aguilo F
No affiliation info available

MeSH

Amino Acid SequenceAnimalsFemaleHumansHypercalcemiaMaleMolecular Sequence DataNeoplasm ProteinsParathyroid HormoneParathyroid Hormone-Related ProteinProteinsReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid Hormone

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9160398

Citation

Alcantara, A, et al. "An Update On the Discovery, Pathophysiological Actions, Clinical Manifestations and Possible Physiology of Parathyroid Related Peptide." Puerto Rico Health Sciences Journal, vol. 16, no. 1, 1997, pp. 15-22.
Alcantara A, Montalvo-Figueroa JA, Toro S, et al. An update on the discovery, pathophysiological actions, clinical manifestations and possible physiology of parathyroid related peptide. P R Health Sci J. 1997;16(1):15-22.
Alcantara, A., Montalvo-Figueroa, J. A., Toro, S., & Aguilo, F. (1997). An update on the discovery, pathophysiological actions, clinical manifestations and possible physiology of parathyroid related peptide. Puerto Rico Health Sciences Journal, 16(1), 15-22.
Alcantara A, et al. An Update On the Discovery, Pathophysiological Actions, Clinical Manifestations and Possible Physiology of Parathyroid Related Peptide. P R Health Sci J. 1997;16(1):15-22. PubMed PMID: 9160398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An update on the discovery, pathophysiological actions, clinical manifestations and possible physiology of parathyroid related peptide. AU - Alcantara,A, AU - Montalvo-Figueroa,J A, AU - Toro,S, AU - Aguilo,F, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 15 EP - 22 JF - Puerto Rico health sciences journal JO - P R Health Sci J VL - 16 IS - 1 N2 - PTHrP has had an unidentified role in medicine since 1930, when Albright described a patient with renal cortical cell carcinoma with hypercalcemia. Since then hypercalcemia has been recognized as the most common paraneoplastic syndrome. At that time the concept of "ectopic PTH syndrome" was introduced, and remained in literature until the true etiology was finally described. In the early 1970's Roof and Benson presented evidence that PTH in humoral hypercalcemia differed from "authentic" PTH. This marked the starting point for researchers to try identifying the molecule that mimicked PTH action and structure. This molecule, named parathyroid-related peptide, has been associated to hypercalcemia seen with solid tumors, such as squamous cell carcinoma of the lung and renal cortical cell carcinoma. PTHrP has been demonstrated to have similar actions to PTH but to differ in decreasing osteoblastic activity while increasing osteoclastic activity. The more fascinating finding was the presence of the PTHrP genes throughout the body, mostly the lactating breast as well as the heart, lungs and skin among others. Despite its identification, finding its physiological roles on normal tissue still remains to be clarified. SN - 0738-0658 UR - https://www.unboundmedicine.com/medline/citation/9160398/An_update_on_the_discovery_pathophysiological_actions_clinical_manifestations_and_possible_physiology_of_parathyroid_related_peptide_ L2 - https://antibodies.cancer.gov/detail/CPTC-PTHrP-1 DB - PRIME DP - Unbound Medicine ER -