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Effect of a diet high in vegetables, fruit, and nuts on serum lipids.

Abstract

We assessed the effect of a diet high in leafy and green vegetables, fruit, and nuts on serum lipid risk factors for cardiovascular disease. Ten healthy volunteers (seven men and three women aged 33 +/- 4 years [mean +/- SEM]; body mass index, 23 +/- 1 kg/m2) consumed their habitual diet (control diet, 29% +/- 2% fat calories) and a diet consisting largely of leafy and other low-calorie vegetables, fruit, and nuts (vegetable diet, 25% +/- 3% fat calories) for two 2-week periods in a randomized crossover design. After 2 weeks on the vegetable diet, lipid risk factors for cardiovascular disease were significantly reduced by comparison with the control diet (low-density lipoprotein [LDL] cholesterol, 33% +/- 4%, P < .001; ratio of total to high-density lipoprotein [HDL] cholesterol, 21% +/- 4%, P < .001; apolipoprotein [apo] B:A-I, 23% +/- 2%, P < .001; and lipoprotein (a) [Lp(a)], 24% +/- 9%, P = .031). The reduction in apo B was related to increased intakes of soluble fiber (r = .84, P = .003) and vegetable protein (r = -.65, P = .041). On the vegetable compared with the control diet, the reduction in total serum cholesterol was 34% to 49% greater than would be predicted by differences in dietary fat and cholesterol. A diet consisting largely of low-calorie vegetables and fruit and nuts markedly reduced lipid risk factors for cardiovascular disease. Several aspects of such diets, which may have been consumed early in human evolution, have implications for cardiovascular disease prevention.

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  • Authors+Show Affiliations

    ,

    Clinical Nutrition and Risk Factor Modification Center, Division of Endocrinology, St. Michael's Hospital, Toronto, Ontario, Canada.

    , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Cardiovascular Diseases
    Cholesterol
    Cross-Over Studies
    Diet
    Female
    Fruit
    Humans
    Lipids
    Male
    Nuts
    Risk Factors
    Vegetables

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9160820

    Citation

    Jenkins, D J., et al. "Effect of a Diet High in Vegetables, Fruit, and Nuts On Serum Lipids." Metabolism: Clinical and Experimental, vol. 46, no. 5, 1997, pp. 530-7.
    Jenkins DJ, Popovich DG, Kendall CW, et al. Effect of a diet high in vegetables, fruit, and nuts on serum lipids. Metab Clin Exp. 1997;46(5):530-7.
    Jenkins, D. J., Popovich, D. G., Kendall, C. W., Vidgen, E., Tariq, N., Ransom, T. P., ... Patten, R. (1997). Effect of a diet high in vegetables, fruit, and nuts on serum lipids. Metabolism: Clinical and Experimental, 46(5), pp. 530-7.
    Jenkins DJ, et al. Effect of a Diet High in Vegetables, Fruit, and Nuts On Serum Lipids. Metab Clin Exp. 1997;46(5):530-7. PubMed PMID: 9160820.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of a diet high in vegetables, fruit, and nuts on serum lipids. AU - Jenkins,D J, AU - Popovich,D G, AU - Kendall,C W, AU - Vidgen,E, AU - Tariq,N, AU - Ransom,T P, AU - Wolever,T M, AU - Vuksan,V, AU - Mehling,C C, AU - Boctor,D L, AU - Bolognesi,C, AU - Huang,J, AU - Patten,R, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 530 EP - 7 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 46 IS - 5 N2 - We assessed the effect of a diet high in leafy and green vegetables, fruit, and nuts on serum lipid risk factors for cardiovascular disease. Ten healthy volunteers (seven men and three women aged 33 +/- 4 years [mean +/- SEM]; body mass index, 23 +/- 1 kg/m2) consumed their habitual diet (control diet, 29% +/- 2% fat calories) and a diet consisting largely of leafy and other low-calorie vegetables, fruit, and nuts (vegetable diet, 25% +/- 3% fat calories) for two 2-week periods in a randomized crossover design. After 2 weeks on the vegetable diet, lipid risk factors for cardiovascular disease were significantly reduced by comparison with the control diet (low-density lipoprotein [LDL] cholesterol, 33% +/- 4%, P < .001; ratio of total to high-density lipoprotein [HDL] cholesterol, 21% +/- 4%, P < .001; apolipoprotein [apo] B:A-I, 23% +/- 2%, P < .001; and lipoprotein (a) [Lp(a)], 24% +/- 9%, P = .031). The reduction in apo B was related to increased intakes of soluble fiber (r = .84, P = .003) and vegetable protein (r = -.65, P = .041). On the vegetable compared with the control diet, the reduction in total serum cholesterol was 34% to 49% greater than would be predicted by differences in dietary fat and cholesterol. A diet consisting largely of low-calorie vegetables and fruit and nuts markedly reduced lipid risk factors for cardiovascular disease. Several aspects of such diets, which may have been consumed early in human evolution, have implications for cardiovascular disease prevention. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/9160820/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(97)90190-6 DB - PRIME DP - Unbound Medicine ER -