Tags

Type your tag names separated by a space and hit enter

Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne.
J Dermatol. 1997 Apr; 24(4):223-9.JD

Abstract

One of the important etiologic factors in acne is an increase in sebaceous gland activity, which is androgen dependent. Acne is a common manifestation of hyperandrogenemia. Therefore, acne may not only cause cosmetic concern but may also be a sign of underlying disease. In females, the most common cause of hyperandrogenemia is polycystic ovary syndrome (PCOS). The purpose of this study was to determine the hormonal profiles of women with acne and the prevalence of PCOS in women attending the dermatological clinic with acne problems. The diagnostic criteria of PCOS were clinical findings of menstrual disturbances and hyperandrogenism (acne, seborrhea, hirsutism), pelvic ultrasound imaging of PCO (multiple subcapsular ovarian cysts 2-8 mm. in diameter, with dense echogenic stroma), and an elevated luteinizing hormone (LH) to follicle stimulating hormone (FSH) ratio. There were 51 women with acne; 20 regularly menstruating volunteers without acne served as a control group. PCOS was found in 19 out of 51 patients with acne (37.3%) and none of the control group. Twenty acne patients had abnormal menstruation (39.2%). Acne cases had higher mean levels of serum total testosterone (T), free T, dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL). No statistically significant difference was observed for LH, FSH or sex hormone binding globulin (SHBG). Because of this high prevalence of PCOS in women with acne, all women presenting with acne should be asked about their menstrual pattern and examined for other signs of hyperandrogenemia. Hormonal profile determination as well as pelvic ultrasonography for ovarian visualization should be performed to confirm the diagnosis of PCOS in female acne patients who have menstrual disturbances.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9164062

Citation

Timpatanapong, P, and A Rojanasakul. "Hormonal Profiles and Prevalence of Polycystic Ovary Syndrome in Women With Acne." The Journal of Dermatology, vol. 24, no. 4, 1997, pp. 223-9.
Timpatanapong P, Rojanasakul A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J Dermatol. 1997;24(4):223-9.
Timpatanapong, P., & Rojanasakul, A. (1997). Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. The Journal of Dermatology, 24(4), 223-9.
Timpatanapong P, Rojanasakul A. Hormonal Profiles and Prevalence of Polycystic Ovary Syndrome in Women With Acne. J Dermatol. 1997;24(4):223-9. PubMed PMID: 9164062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. AU - Timpatanapong,P, AU - Rojanasakul,A, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 223 EP - 9 JF - The Journal of dermatology JO - J Dermatol VL - 24 IS - 4 N2 - One of the important etiologic factors in acne is an increase in sebaceous gland activity, which is androgen dependent. Acne is a common manifestation of hyperandrogenemia. Therefore, acne may not only cause cosmetic concern but may also be a sign of underlying disease. In females, the most common cause of hyperandrogenemia is polycystic ovary syndrome (PCOS). The purpose of this study was to determine the hormonal profiles of women with acne and the prevalence of PCOS in women attending the dermatological clinic with acne problems. The diagnostic criteria of PCOS were clinical findings of menstrual disturbances and hyperandrogenism (acne, seborrhea, hirsutism), pelvic ultrasound imaging of PCO (multiple subcapsular ovarian cysts 2-8 mm. in diameter, with dense echogenic stroma), and an elevated luteinizing hormone (LH) to follicle stimulating hormone (FSH) ratio. There were 51 women with acne; 20 regularly menstruating volunteers without acne served as a control group. PCOS was found in 19 out of 51 patients with acne (37.3%) and none of the control group. Twenty acne patients had abnormal menstruation (39.2%). Acne cases had higher mean levels of serum total testosterone (T), free T, dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL). No statistically significant difference was observed for LH, FSH or sex hormone binding globulin (SHBG). Because of this high prevalence of PCOS in women with acne, all women presenting with acne should be asked about their menstrual pattern and examined for other signs of hyperandrogenemia. Hormonal profile determination as well as pelvic ultrasonography for ovarian visualization should be performed to confirm the diagnosis of PCOS in female acne patients who have menstrual disturbances. SN - 0385-2407 UR - https://www.unboundmedicine.com/medline/citation/9164062/Hormonal_profiles_and_prevalence_of_polycystic_ovary_syndrome_in_women_with_acne_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0385-2407&date=1997&volume=24&issue=4&spage=223 DB - PRIME DP - Unbound Medicine ER -