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Cocaine--stimulus generalization to MDA optical isomers: a reevaluation.
Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):115-8.PB

Abstract

It has already been demonstrated that the psychoactive agent 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) produces effects that are both hallucinogen-like and amphetamine or stimulant-like in animals. Hallucinogenic activity is associated primarily with the R(-)-isomer of MDA whereas stimulant activity is primarily associated with the S(+)-isomer. Because a previous report indicates that S(+)MDA fails to substitute for cocaine in rats trained to discriminate cocaine from vehicle, and because these findings are inconsistent with the purported stimulant nature of S(+)MDA, we reinvestigated the effect of both MDA isomers in rats. In this investigation, S(+)MDA doses of 1.25 and 1.5 mg/kg were found to produce > 80% cocaine-appropriate responding in rats trained to discriminate 8 mg/kg of cocaine from saline. However, consistent with a previous report, R(-)MDA resulted only in partial generalization. These new results support the hypothesis that the optical isomers of MDA produce distinguishable stimulus effects in rats and that S(+)MDA is the more stimulant isomer of MDA.

Authors+Show Affiliations

Department of Medicinal Chemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9164561

Citation

Young, R, and R A. Glennon. "Cocaine--stimulus Generalization to MDA Optical Isomers: a Reevaluation." Pharmacology, Biochemistry, and Behavior, vol. 57, no. 1-2, 1997, pp. 115-8.
Young R, Glennon RA. Cocaine--stimulus generalization to MDA optical isomers: a reevaluation. Pharmacol Biochem Behav. 1997;57(1-2):115-8.
Young, R., & Glennon, R. A. (1997). Cocaine--stimulus generalization to MDA optical isomers: a reevaluation. Pharmacology, Biochemistry, and Behavior, 57(1-2), 115-8.
Young R, Glennon RA. Cocaine--stimulus Generalization to MDA Optical Isomers: a Reevaluation. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):115-8. PubMed PMID: 9164561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cocaine--stimulus generalization to MDA optical isomers: a reevaluation. AU - Young,R, AU - Glennon,R A, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 115 EP - 8 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 57 IS - 1-2 N2 - It has already been demonstrated that the psychoactive agent 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) produces effects that are both hallucinogen-like and amphetamine or stimulant-like in animals. Hallucinogenic activity is associated primarily with the R(-)-isomer of MDA whereas stimulant activity is primarily associated with the S(+)-isomer. Because a previous report indicates that S(+)MDA fails to substitute for cocaine in rats trained to discriminate cocaine from vehicle, and because these findings are inconsistent with the purported stimulant nature of S(+)MDA, we reinvestigated the effect of both MDA isomers in rats. In this investigation, S(+)MDA doses of 1.25 and 1.5 mg/kg were found to produce > 80% cocaine-appropriate responding in rats trained to discriminate 8 mg/kg of cocaine from saline. However, consistent with a previous report, R(-)MDA resulted only in partial generalization. These new results support the hypothesis that the optical isomers of MDA produce distinguishable stimulus effects in rats and that S(+)MDA is the more stimulant isomer of MDA. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/9164561/Cocaine__stimulus_generalization_to_MDA_optical_isomers:_a_reevaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(96)00352-8 DB - PRIME DP - Unbound Medicine ER -