Tags

Type your tag names separated by a space and hit enter

Initial characterization of PMMA as a discriminative stimulus.
Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):151-8.PB

Abstract

The phenylisopropylamine PMMA or N-methyl-1-(4-methoxyphenyl)-2-aminopropane, a structural hybrid of paramethoxyamphetamine (PMA) and methamphetamine, has been previously shown to unexpectedly lack amphetamine-like or hallucinogen-like stimulus properties in animals. For example, in tests of stimulus generalization, neither a (+)amphetamine stimulus nor a DOM stimulus generalized to PMMA. It has also been shown, however, that stimulus generalization does occur in animals trained to discriminate the designer drug MDMA ("Ecstasy" or N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane) from vehicle. In order to further characterize this unique agent, we trained a group of six Sprague-Dawley rats to discriminate 1.25 mg/kg of PMMA (ED50 = 0.44 mg/kg) from saline vehicle. The PMMA stimulus failed to generalize to the phenylisopropylamine stimulant (+)amphetamine, or to the phenylisopropylamine hallucinogen DOM. Stimulus generalization occurred to (+/-)MDMA (ED50 = 1.32 mg/kg) and S(+)MDMA (ED50 = 0.48 mg/kg). Partial generalization occurred with R(+)MDMA, PMA, 3.4-DMA, and fenfluramine. The PMMA stimulus also generalized to the alpha-ethyl homolog of PMMA (EH/PMMA, ED50 = 1.29 mg/kg). Taken together, the results of these studies suggest that PMMA is an MDMA-like agent that lacks the amphetamine-like stimulant character of MDMA. These findings support our previous suggestion that PMMA be considered the structural parent of the MDMA-like family of designer drugs.

Authors+Show Affiliations

Department of Medicinal Chemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0540, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9164566

Citation

Glennon, R A., et al. "Initial Characterization of PMMA as a Discriminative Stimulus." Pharmacology, Biochemistry, and Behavior, vol. 57, no. 1-2, 1997, pp. 151-8.
Glennon RA, Young R, Dukat M, et al. Initial characterization of PMMA as a discriminative stimulus. Pharmacol Biochem Behav. 1997;57(1-2):151-8.
Glennon, R. A., Young, R., Dukat, M., & Cheng, Y. (1997). Initial characterization of PMMA as a discriminative stimulus. Pharmacology, Biochemistry, and Behavior, 57(1-2), 151-8.
Glennon RA, et al. Initial Characterization of PMMA as a Discriminative Stimulus. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):151-8. PubMed PMID: 9164566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Initial characterization of PMMA as a discriminative stimulus. AU - Glennon,R A, AU - Young,R, AU - Dukat,M, AU - Cheng,Y, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 151 EP - 8 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 57 IS - 1-2 N2 - The phenylisopropylamine PMMA or N-methyl-1-(4-methoxyphenyl)-2-aminopropane, a structural hybrid of paramethoxyamphetamine (PMA) and methamphetamine, has been previously shown to unexpectedly lack amphetamine-like or hallucinogen-like stimulus properties in animals. For example, in tests of stimulus generalization, neither a (+)amphetamine stimulus nor a DOM stimulus generalized to PMMA. It has also been shown, however, that stimulus generalization does occur in animals trained to discriminate the designer drug MDMA ("Ecstasy" or N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane) from vehicle. In order to further characterize this unique agent, we trained a group of six Sprague-Dawley rats to discriminate 1.25 mg/kg of PMMA (ED50 = 0.44 mg/kg) from saline vehicle. The PMMA stimulus failed to generalize to the phenylisopropylamine stimulant (+)amphetamine, or to the phenylisopropylamine hallucinogen DOM. Stimulus generalization occurred to (+/-)MDMA (ED50 = 1.32 mg/kg) and S(+)MDMA (ED50 = 0.48 mg/kg). Partial generalization occurred with R(+)MDMA, PMA, 3.4-DMA, and fenfluramine. The PMMA stimulus also generalized to the alpha-ethyl homolog of PMMA (EH/PMMA, ED50 = 1.29 mg/kg). Taken together, the results of these studies suggest that PMMA is an MDMA-like agent that lacks the amphetamine-like stimulant character of MDMA. These findings support our previous suggestion that PMMA be considered the structural parent of the MDMA-like family of designer drugs. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/9164566/Initial_characterization_of_PMMA_as_a_discriminative_stimulus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(96)00306-1 DB - PRIME DP - Unbound Medicine ER -