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High density lipoprotein apolipoprotein AI kinetics in NIDDM: a stable isotope study.
Diabetologia. 1997 May; 40(5):578-83.D

Abstract

High density lipoprotein (HDL) kinetics were studied by infusing [5,5,5-2H3]-leucine in five subjects with normal glucose tolerance and eight patients with non-insulin-dependent diabetes mellitus (NIDDM) with poor metabolic control (HbA1c = 8.16 +/- 1.93%) (mean +/- SD). HDL were modelled as a single compartment since no kinetic differences were observed between HDL2 and HDL3 subclasses. Plasma apolipoprotein AI (apo AI) concentration was significantly lower in NIDDM patients (96.1 +/- 12.1 vs 124.4 +/- 13.1 mg.dl-1, p < 0.01). HDL composition was altered in NIDDM, as an increase in HDL-triglyceride and a decrease in HDL-cholesterol, negatively correlated (r = 0.780, p < 0.01). The mean fractional catabolic rate (FCR) of apo AI-HDL was significantly higher (0.39 +/- 0.16 vs 0.21 +/- 0.06 d-1, p < 0.05) while the apo AI-HDL absolute production rate was not significantly greater (13.6 +/- 5.1 vs 12.0 +/- 4.2 mg.kg-1.d-1) in diabetic patients compared to normal subjects. There were significant correlations between apo AI-HDL FCR and plasma apo AI concentration (r = -0.580, p < 0.05), plasma triglycerides (r = 0.839, p < 0.0001) or HDL-triglyceride levels (r = 0.597, p < 0.05). No correlation was observed between apo AI-HDL FCR and HbA1c or HDL-cholesterol level. These data support the view that the decrease in plasma apo AI level in patients with NIDDM is due to an increase of apo AI-HDL FCR, which may itself be related to changes in HDL composition.

Authors+Show Affiliations

Center de Recherche en Nutrition Humaine, Hôpital G. & R. Laënnec, Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9165227

Citation

Frénais, R, et al. "High Density Lipoprotein Apolipoprotein AI Kinetics in NIDDM: a Stable Isotope Study." Diabetologia, vol. 40, no. 5, 1997, pp. 578-83.
Frénais R, Ouguerram K, Maugeais C, et al. High density lipoprotein apolipoprotein AI kinetics in NIDDM: a stable isotope study. Diabetologia. 1997;40(5):578-83.
Frénais, R., Ouguerram, K., Maugeais, C., Mahot, P., Maugère, P., Krempf, M., & Magot, T. (1997). High density lipoprotein apolipoprotein AI kinetics in NIDDM: a stable isotope study. Diabetologia, 40(5), 578-83.
Frénais R, et al. High Density Lipoprotein Apolipoprotein AI Kinetics in NIDDM: a Stable Isotope Study. Diabetologia. 1997;40(5):578-83. PubMed PMID: 9165227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High density lipoprotein apolipoprotein AI kinetics in NIDDM: a stable isotope study. AU - Frénais,R, AU - Ouguerram,K, AU - Maugeais,C, AU - Mahot,P, AU - Maugère,P, AU - Krempf,M, AU - Magot,T, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 578 EP - 83 JF - Diabetologia JO - Diabetologia VL - 40 IS - 5 N2 - High density lipoprotein (HDL) kinetics were studied by infusing [5,5,5-2H3]-leucine in five subjects with normal glucose tolerance and eight patients with non-insulin-dependent diabetes mellitus (NIDDM) with poor metabolic control (HbA1c = 8.16 +/- 1.93%) (mean +/- SD). HDL were modelled as a single compartment since no kinetic differences were observed between HDL2 and HDL3 subclasses. Plasma apolipoprotein AI (apo AI) concentration was significantly lower in NIDDM patients (96.1 +/- 12.1 vs 124.4 +/- 13.1 mg.dl-1, p < 0.01). HDL composition was altered in NIDDM, as an increase in HDL-triglyceride and a decrease in HDL-cholesterol, negatively correlated (r = 0.780, p < 0.01). The mean fractional catabolic rate (FCR) of apo AI-HDL was significantly higher (0.39 +/- 0.16 vs 0.21 +/- 0.06 d-1, p < 0.05) while the apo AI-HDL absolute production rate was not significantly greater (13.6 +/- 5.1 vs 12.0 +/- 4.2 mg.kg-1.d-1) in diabetic patients compared to normal subjects. There were significant correlations between apo AI-HDL FCR and plasma apo AI concentration (r = -0.580, p < 0.05), plasma triglycerides (r = 0.839, p < 0.0001) or HDL-triglyceride levels (r = 0.597, p < 0.05). No correlation was observed between apo AI-HDL FCR and HbA1c or HDL-cholesterol level. These data support the view that the decrease in plasma apo AI level in patients with NIDDM is due to an increase of apo AI-HDL FCR, which may itself be related to changes in HDL composition. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/9165227/High_density_lipoprotein_apolipoprotein_AI_kinetics_in_NIDDM:_a_stable_isotope_study_ L2 - https://doi.org/10.1007/s001250050718 DB - PRIME DP - Unbound Medicine ER -