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Clinical enuresis phenotypes in familial nocturnal enuresis.
Scand J Urol Nephrol Suppl. 1997; 183:11-6.SJ

Abstract

The objective of the current study was to identify the associations between phenotype and genotype in children with nocturnal enuresis. Of the total of 167 wetting children, aged 5-10 years, without neurological or structural forms of incontinence, 110 were nocturnal enuretics. The examinations included a full psychiatric and psychological assessment, a paediatric and neurological examination, a family history with pedigree, ultrasonography, uroflowmetery, urinanalysis and bacteriology. Children with secondary nocturnal enuresis (n = 28) had a significantly higher rate of behavioural disorders, life events and continuous psychosocial stress than those with primary nocturnal enuresis (n = 82). Of the latter group, children with primary monosymptomatic nocturnal enuresis (n = 50) had an especially low rate of behavioural problems, when in comparison to primary non-monosymptomatic nocturnal enuretics (n = 32). Formal genetics point to a high genetic predisposition to nocturnal enuresis in all subgroups. Linkage studies to markers on chromosomes 8, 12 and 13 demonstrate both clinical, as well as genetic heterogeneity in nocturnal enuresis.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, University of Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9165597

Citation

von Gontard, A, et al. "Clinical Enuresis Phenotypes in Familial Nocturnal Enuresis." Scandinavian Journal of Urology and Nephrology. Supplementum, vol. 183, 1997, pp. 11-6.
von Gontard A, Hollmann E, Eiberg H, et al. Clinical enuresis phenotypes in familial nocturnal enuresis. Scand J Urol Nephrol Suppl. 1997;183:11-6.
von Gontard, A., Hollmann, E., Eiberg, H., Benden, B., Rittig, S., & Lehmkuhl, G. (1997). Clinical enuresis phenotypes in familial nocturnal enuresis. Scandinavian Journal of Urology and Nephrology. Supplementum, 183, 11-6.
von Gontard A, et al. Clinical Enuresis Phenotypes in Familial Nocturnal Enuresis. Scand J Urol Nephrol Suppl. 1997;183:11-6. PubMed PMID: 9165597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical enuresis phenotypes in familial nocturnal enuresis. AU - von Gontard,A, AU - Hollmann,E, AU - Eiberg,H, AU - Benden,B, AU - Rittig,S, AU - Lehmkuhl,G, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 11 EP - 6 JF - Scandinavian journal of urology and nephrology. Supplementum JO - Scand J Urol Nephrol Suppl VL - 183 N2 - The objective of the current study was to identify the associations between phenotype and genotype in children with nocturnal enuresis. Of the total of 167 wetting children, aged 5-10 years, without neurological or structural forms of incontinence, 110 were nocturnal enuretics. The examinations included a full psychiatric and psychological assessment, a paediatric and neurological examination, a family history with pedigree, ultrasonography, uroflowmetery, urinanalysis and bacteriology. Children with secondary nocturnal enuresis (n = 28) had a significantly higher rate of behavioural disorders, life events and continuous psychosocial stress than those with primary nocturnal enuresis (n = 82). Of the latter group, children with primary monosymptomatic nocturnal enuresis (n = 50) had an especially low rate of behavioural problems, when in comparison to primary non-monosymptomatic nocturnal enuretics (n = 32). Formal genetics point to a high genetic predisposition to nocturnal enuresis in all subgroups. Linkage studies to markers on chromosomes 8, 12 and 13 demonstrate both clinical, as well as genetic heterogeneity in nocturnal enuresis. SN - 0300-8886 UR - https://www.unboundmedicine.com/medline/citation/9165597/Clinical_enuresis_phenotypes_in_familial_nocturnal_enuresis_ L2 - https://medlineplus.gov/urinaryincontinence.html DB - PRIME DP - Unbound Medicine ER -