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Effects of baicalein on prostanoid generation from the lung and contractile responses of the trachea in guinea pig.
Am J Chin Med. 1997; 25(1):37-50.AJ

Abstract

Effects of baicalein on release of slow reacting substance of anaphylaxis (SRS-A) or leukotriene (LT) from the sensitized guinea pig lung after antigen challenge and tonus of guinea pig tracheal muscles were studied. Baicalein inhibited release of SRS-A from sensitized guinea pig lung after antigen challenge. High-performance liquid chromatography (HPLC) analysis revealed that released SRS-A consisted to LTC4 and D4. Baicalein also reduced release of LTC4 and D4 from the sensitized lung after antigen challenge. Baicalein relaxed the isolated guinea pig tracheal smooth muscle contracted by LTD4, carbachol or histamine. However, this compound produced a contraction when the tracheal muscle was contracted by prostaglandin F2 alpha(PGF2 alpha). This contraction by baicalein was abolished by pretreatment with indomethacin, a cyclooxygenase inhibitor. Baicalein elicited a relaxation in the normal non-sensitized preparation but a contraction in the tissue isolated from actively sensitized guinea pig in 4 among 7 cases. Baicalein also produced a contraction in the trachea pretreated with phorbol dibutyrate and contracted by carbachol, which was eliminated after treatment with indomethacin. The results suggest that baicalein exerts action via, at least, two different mechanisms, the inhibition of releasing SRS-A (LTs) and direct relaxing effects on the trachea. Besides, baicalein seems to produce contraction under certain conditions, which may involve stimulation of the cyclooxygenase pathway.

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Authors+Show Affiliations

Miyamoto K
Department of Pharmacology, Fukuoka University School Medicine, Japan.
Katsuragi T
No affiliation info available
Abdu P
No affiliation info available
Furukawa T
No affiliation info available

MeSH

AnimalsBiological AssayChromatography, High Pressure LiquidCyclooxygenase InhibitorsDinoprostDose-Response Relationship, DrugEnzyme ActivationEnzyme InhibitorsFlavanonesFlavonoidsGuinea PigsIleumIndomethacinLungMaleMuscle ContractionMuscle, SmoothOvalbuminOxytocicsProtein Kinase CSRS-ATrachea

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9166996

Citation

Miyamoto, K, et al. "Effects of Baicalein On Prostanoid Generation From the Lung and Contractile Responses of the Trachea in Guinea Pig." The American Journal of Chinese Medicine, vol. 25, no. 1, 1997, pp. 37-50.
Miyamoto K, Katsuragi T, Abdu P, et al. Effects of baicalein on prostanoid generation from the lung and contractile responses of the trachea in guinea pig. Am J Chin Med. 1997;25(1):37-50.
Miyamoto, K., Katsuragi, T., Abdu, P., & Furukawa, T. (1997). Effects of baicalein on prostanoid generation from the lung and contractile responses of the trachea in guinea pig. The American Journal of Chinese Medicine, 25(1), 37-50.
Miyamoto K, et al. Effects of Baicalein On Prostanoid Generation From the Lung and Contractile Responses of the Trachea in Guinea Pig. Am J Chin Med. 1997;25(1):37-50. PubMed PMID: 9166996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of baicalein on prostanoid generation from the lung and contractile responses of the trachea in guinea pig. AU - Miyamoto,K, AU - Katsuragi,T, AU - Abdu,P, AU - Furukawa,T, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 37 EP - 50 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 25 IS - 1 N2 - Effects of baicalein on release of slow reacting substance of anaphylaxis (SRS-A) or leukotriene (LT) from the sensitized guinea pig lung after antigen challenge and tonus of guinea pig tracheal muscles were studied. Baicalein inhibited release of SRS-A from sensitized guinea pig lung after antigen challenge. High-performance liquid chromatography (HPLC) analysis revealed that released SRS-A consisted to LTC4 and D4. Baicalein also reduced release of LTC4 and D4 from the sensitized lung after antigen challenge. Baicalein relaxed the isolated guinea pig tracheal smooth muscle contracted by LTD4, carbachol or histamine. However, this compound produced a contraction when the tracheal muscle was contracted by prostaglandin F2 alpha(PGF2 alpha). This contraction by baicalein was abolished by pretreatment with indomethacin, a cyclooxygenase inhibitor. Baicalein elicited a relaxation in the normal non-sensitized preparation but a contraction in the tissue isolated from actively sensitized guinea pig in 4 among 7 cases. Baicalein also produced a contraction in the trachea pretreated with phorbol dibutyrate and contracted by carbachol, which was eliminated after treatment with indomethacin. The results suggest that baicalein exerts action via, at least, two different mechanisms, the inhibition of releasing SRS-A (LTs) and direct relaxing effects on the trachea. Besides, baicalein seems to produce contraction under certain conditions, which may involve stimulation of the cyclooxygenase pathway. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/9166996/Effects_of_baicalein_on_prostanoid_generation_from_the_lung_and_contractile_responses_of_the_trachea_in_guinea_pig_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X9700007X?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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