Tags

Type your tag names separated by a space and hit enter

Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs.
J Toxicol Environ Health. 1997 May; 51(1):77-87.JT

Abstract

The effect of prior ozone (O3) exposure on airway hyperresponsiveness and inflammation induced by trimellitic anhydride (TMA) has been investigated in TMA-sensitized guinea pigs. Airway responsiveness was measured as the concentration of acetylcholine needed to increase baseline lung resistance (RL) by 300% (PC300). Ozone (3 ppm for 3 h) caused an increase in -log PC300 at 1 h after exposure, with return of -log PC300 to control levels at 8 h. Ozone also increased baseline RL at 8 h. TMA challenge increase -log PC300 in TMA-sensitized guinea pigs at 8 h after challenge from 3.85 +/- 0.09 to 4.11 +/- 0.09. Ozone exposure prior to TMA challenge prevented the induction of airway hyperresponsiveness with a mean -log PC300 of 3.51 +/- 0.20, which was not different from that of control TMA-sensitized group. Baseline RL was significantly higher in ozone-pretreated animals after TMA challenge when compared to those of either control or challenged with TMA alone. Ozone had no effect on TMA challenge-induced BAL eosinophilia and neutrophilia. We conclude that a single exposure to ozone inhibits the increase in airway responsiveness but increases the bronchoconstrictor response induced by TMA in TMA-sensitized guinea pigs; however, the inflammatory airway response to TMA is unchanged by preexposure to ozone.

Authors+Show Affiliations

Department of Thoracic Medicine, National Heart & Lung Institute, London, United Kingdom.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9169062

Citation

Sun, J, and K F. Chung. "Interaction of Ozone Exposure With Airway Hyperresponsiveness and Inflammation Induced By Trimellitic Anhydride in Sensitized Guinea Pigs." Journal of Toxicology and Environmental Health, vol. 51, no. 1, 1997, pp. 77-87.
Sun J, Chung KF. Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs. J Toxicol Environ Health. 1997;51(1):77-87.
Sun, J., & Chung, K. F. (1997). Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs. Journal of Toxicology and Environmental Health, 51(1), 77-87.
Sun J, Chung KF. Interaction of Ozone Exposure With Airway Hyperresponsiveness and Inflammation Induced By Trimellitic Anhydride in Sensitized Guinea Pigs. J Toxicol Environ Health. 1997;51(1):77-87. PubMed PMID: 9169062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs. AU - Sun,J, AU - Chung,K F, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 77 EP - 87 JF - Journal of toxicology and environmental health JO - J Toxicol Environ Health VL - 51 IS - 1 N2 - The effect of prior ozone (O3) exposure on airway hyperresponsiveness and inflammation induced by trimellitic anhydride (TMA) has been investigated in TMA-sensitized guinea pigs. Airway responsiveness was measured as the concentration of acetylcholine needed to increase baseline lung resistance (RL) by 300% (PC300). Ozone (3 ppm for 3 h) caused an increase in -log PC300 at 1 h after exposure, with return of -log PC300 to control levels at 8 h. Ozone also increased baseline RL at 8 h. TMA challenge increase -log PC300 in TMA-sensitized guinea pigs at 8 h after challenge from 3.85 +/- 0.09 to 4.11 +/- 0.09. Ozone exposure prior to TMA challenge prevented the induction of airway hyperresponsiveness with a mean -log PC300 of 3.51 +/- 0.20, which was not different from that of control TMA-sensitized group. Baseline RL was significantly higher in ozone-pretreated animals after TMA challenge when compared to those of either control or challenged with TMA alone. Ozone had no effect on TMA challenge-induced BAL eosinophilia and neutrophilia. We conclude that a single exposure to ozone inhibits the increase in airway responsiveness but increases the bronchoconstrictor response induced by TMA in TMA-sensitized guinea pigs; however, the inflammatory airway response to TMA is unchanged by preexposure to ozone. SN - 0098-4108 UR - https://www.unboundmedicine.com/medline/citation/9169062/Interaction_of_ozone_exposure_with_airway_hyperresponsiveness_and_inflammation_induced_by_trimellitic_anhydride_in_sensitized_guinea_pigs_ L2 - https://medlineplus.gov/acutebronchitis.html DB - PRIME DP - Unbound Medicine ER -