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Management of microcalcifications that develop at the lumpectomy site after breast-conserving therapy.
Radiology. 1997 Jun; 203(3):667-71.R

Abstract

PURPOSE

To design a decision tree according to time from irradiation and site, morphology, and number of microcalcifications for the rational treatment of patients with microcalcifications at the lumpectomy site after breast-conserving therapy (BCT), to minimize performance of biopsy.

MATERIALS AND METHODS

From a database of 504 women selected to receive BCT, those developing probably benign microcalcifications within 3 years of BCT received close follow-up with mammography. Patients developing fewer than four probably benign microcalcifications more than 3 years after treatment were offered mammography or biopsy. If microcalcifications appeared malignant or patients developed four or more microcalcifications after 3 years, biopsy was performed.

RESULTS

Twenty-eight patients (29 breasts [5.7%]) developed microcalcifications confined to the lumpectomy site. Fifteen patients (15 breasts) developed microcalcifications within 3 years of BCT and were followed up with mammography. Thirteen patients (14 breasts) developed microcalcifications confined to the lumpectomy site after more than 3 years. Among the latter group, microcalcifications appeared malignant in four breasts, and biopsy specimens revealed three recurrences. The remaining 10 breasts were followed up with mammography. No patient undergoing mammographic follow-up without biopsy has had clinical evidence of local failure throughout the follow-up period.

CONCLUSION

Follow-up mammography is an option when benign-appearing microcalcifications develop at the lumpectomy site depending on time of appearance and number; it is the primary recommendation when these microcalcifications develop within 3 years after treatment.

Authors+Show Affiliations

Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9169686

Citation

Vora, S A., et al. "Management of Microcalcifications That Develop at the Lumpectomy Site After Breast-conserving Therapy." Radiology, vol. 203, no. 3, 1997, pp. 667-71.
Vora SA, Wazer DE, Homer MJ. Management of microcalcifications that develop at the lumpectomy site after breast-conserving therapy. Radiology. 1997;203(3):667-71.
Vora, S. A., Wazer, D. E., & Homer, M. J. (1997). Management of microcalcifications that develop at the lumpectomy site after breast-conserving therapy. Radiology, 203(3), 667-71.
Vora SA, Wazer DE, Homer MJ. Management of Microcalcifications That Develop at the Lumpectomy Site After Breast-conserving Therapy. Radiology. 1997;203(3):667-71. PubMed PMID: 9169686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of microcalcifications that develop at the lumpectomy site after breast-conserving therapy. AU - Vora,S A, AU - Wazer,D E, AU - Homer,M J, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 667 EP - 71 JF - Radiology JO - Radiology VL - 203 IS - 3 N2 - PURPOSE: To design a decision tree according to time from irradiation and site, morphology, and number of microcalcifications for the rational treatment of patients with microcalcifications at the lumpectomy site after breast-conserving therapy (BCT), to minimize performance of biopsy. MATERIALS AND METHODS: From a database of 504 women selected to receive BCT, those developing probably benign microcalcifications within 3 years of BCT received close follow-up with mammography. Patients developing fewer than four probably benign microcalcifications more than 3 years after treatment were offered mammography or biopsy. If microcalcifications appeared malignant or patients developed four or more microcalcifications after 3 years, biopsy was performed. RESULTS: Twenty-eight patients (29 breasts [5.7%]) developed microcalcifications confined to the lumpectomy site. Fifteen patients (15 breasts) developed microcalcifications within 3 years of BCT and were followed up with mammography. Thirteen patients (14 breasts) developed microcalcifications confined to the lumpectomy site after more than 3 years. Among the latter group, microcalcifications appeared malignant in four breasts, and biopsy specimens revealed three recurrences. The remaining 10 breasts were followed up with mammography. No patient undergoing mammographic follow-up without biopsy has had clinical evidence of local failure throughout the follow-up period. CONCLUSION: Follow-up mammography is an option when benign-appearing microcalcifications develop at the lumpectomy site depending on time of appearance and number; it is the primary recommendation when these microcalcifications develop within 3 years after treatment. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/9169686/Management_of_microcalcifications_that_develop_at_the_lumpectomy_site_after_breast_conserving_therapy_ L2 - https://pubs.rsna.org/doi/10.1148/radiology.203.3.9169686?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -