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Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus.
Diabet Med. 1997 May; 14(5):376-80.DM

Abstract

In non-diabetic subjects, insulin concentrations and insulin resistance are clearly connected, and both correlate with leptin levels, making interpretations about mechanisms difficult. In non-insulin-dependent (Type 2) diabetes mellitus (NIDDM), however, insulin concentrations and insulin resistance are less closely associated. Therefore, we examined the relationship of plasma leptin concentrations within insulin resistance and insulin levels in 32 subjects with NIDDM, who underwent measurement of insulin resistance with an insulin sensitivity test. Plasma leptin was measured with an in-house monoclonal immunoradiometric assay. Fasting leptin level correlated with BMI (r = 0.78; p < 0.001), metabolic clearance rate of glucose (= -0.44; p = 0.015), and fasting specific insulin (r = 0.58; p = 0.001), but not with age, cholesterol, triglycerides or blood pressure (r = -0.26 to 0.21; p = NS). In linear regression analysis, after adjustment for BMI and gender, leptin concentrations correlated with those of insulin (partial r = 0.42; p = 0.025), but not insulin resistance (partial r = -0.10; p = NS). We conclude that in NIDDM, concentrations of plasma leptin are closely related to those of insulin per se and to obesity, but not to insulin resistance. Insulin may be an important regulator of leptin concentration in NIDDM.

Authors+Show Affiliations

University College London School of Medicine, Centre for Diabetes and Cardiovascular Risk, Whittington Hospital, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9171253

Citation

Mohamed-Ali, V, et al. "Relationships Between Plasma Leptin and Insulin Concentrations, but Not Insulin Resistance, in Non-insulin-dependent (type 2) Diabetes Mellitus." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 14, no. 5, 1997, pp. 376-80.
Mohamed-Ali V, Pinkney JH, Panahloo A, et al. Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. Diabet Med. 1997;14(5):376-80.
Mohamed-Ali, V., Pinkney, J. H., Panahloo, A., Goodrick, S., Coppack, S. W., & Yudkin, J. S. (1997). Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association, 14(5), 376-80.
Mohamed-Ali V, et al. Relationships Between Plasma Leptin and Insulin Concentrations, but Not Insulin Resistance, in Non-insulin-dependent (type 2) Diabetes Mellitus. Diabet Med. 1997;14(5):376-80. PubMed PMID: 9171253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. AU - Mohamed-Ali,V, AU - Pinkney,J H, AU - Panahloo,A, AU - Goodrick,S, AU - Coppack,S W, AU - Yudkin,J S, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 376 EP - 80 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 14 IS - 5 N2 - In non-diabetic subjects, insulin concentrations and insulin resistance are clearly connected, and both correlate with leptin levels, making interpretations about mechanisms difficult. In non-insulin-dependent (Type 2) diabetes mellitus (NIDDM), however, insulin concentrations and insulin resistance are less closely associated. Therefore, we examined the relationship of plasma leptin concentrations within insulin resistance and insulin levels in 32 subjects with NIDDM, who underwent measurement of insulin resistance with an insulin sensitivity test. Plasma leptin was measured with an in-house monoclonal immunoradiometric assay. Fasting leptin level correlated with BMI (r = 0.78; p < 0.001), metabolic clearance rate of glucose (= -0.44; p = 0.015), and fasting specific insulin (r = 0.58; p = 0.001), but not with age, cholesterol, triglycerides or blood pressure (r = -0.26 to 0.21; p = NS). In linear regression analysis, after adjustment for BMI and gender, leptin concentrations correlated with those of insulin (partial r = 0.42; p = 0.025), but not insulin resistance (partial r = -0.10; p = NS). We conclude that in NIDDM, concentrations of plasma leptin are closely related to those of insulin per se and to obesity, but not to insulin resistance. Insulin may be an important regulator of leptin concentration in NIDDM. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/9171253/Relationships_between_plasma_leptin_and_insulin_concentrations_but_not_insulin_resistance_in_non_insulin_dependent__type_2__diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -