Tags

Type your tag names separated by a space and hit enter

Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography.
J Chromatogr Sci. 1997 Jun; 35(6):275-9.JC

Abstract

Thirteen antihistaminic drugs and their analogues are tested for their extraction by headspace solid-phase microextraction from human whole blood and urine. Their determination is made by using capillary gas chromatography with flame ionization detection. Relatively high recoveries are obtained for terodiline, diphenhydramine, diphenylpyraline, and orphenadrine in urine; but the recoveries in blood extracts are 4-51 times lower than those in urine extracts for all drugs. Benactyzine and piperilate are not suited for the extraction method. The calibration curves are drawn for four drugs spiked to whole blood and for eleven drugs spiked to urine; excellent linearity is confirmed for the drugs. The detection limits for the drugs are 76-473 ng/mL in blood and 13-186 ng/mL in urine. Diphenhydramine is determined for whole blood obtained from a male subject who had received oral administration of 30 mg diphenhydramine-HCl 150 min before the sampling; the concentrations of the drug are 0.12 and 1.22 micrograms/mL for blood and urine, respectively.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

9172412

Citation

Nishikawa, M, et al. "Simple Analysis of Diphenylmethane Antihistaminics and Their Analogues in Bodily Fluids By Headspace Solid-phase Microextraction-capillary Gas Chromatography." Journal of Chromatographic Science, vol. 35, no. 6, 1997, pp. 275-9.
Nishikawa M, Seno H, Ishii A, et al. Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography. J Chromatogr Sci. 1997;35(6):275-9.
Nishikawa, M., Seno, H., Ishii, A., Suzuki, O., Kumazawa, T., Watanabe, K., & Hattori, H. (1997). Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography. Journal of Chromatographic Science, 35(6), 275-9.
Nishikawa M, et al. Simple Analysis of Diphenylmethane Antihistaminics and Their Analogues in Bodily Fluids By Headspace Solid-phase Microextraction-capillary Gas Chromatography. J Chromatogr Sci. 1997;35(6):275-9. PubMed PMID: 9172412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography. AU - Nishikawa,M, AU - Seno,H, AU - Ishii,A, AU - Suzuki,O, AU - Kumazawa,T, AU - Watanabe,K, AU - Hattori,H, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 275 EP - 9 JF - Journal of chromatographic science JO - J Chromatogr Sci VL - 35 IS - 6 N2 - Thirteen antihistaminic drugs and their analogues are tested for their extraction by headspace solid-phase microextraction from human whole blood and urine. Their determination is made by using capillary gas chromatography with flame ionization detection. Relatively high recoveries are obtained for terodiline, diphenhydramine, diphenylpyraline, and orphenadrine in urine; but the recoveries in blood extracts are 4-51 times lower than those in urine extracts for all drugs. Benactyzine and piperilate are not suited for the extraction method. The calibration curves are drawn for four drugs spiked to whole blood and for eleven drugs spiked to urine; excellent linearity is confirmed for the drugs. The detection limits for the drugs are 76-473 ng/mL in blood and 13-186 ng/mL in urine. Diphenhydramine is determined for whole blood obtained from a male subject who had received oral administration of 30 mg diphenhydramine-HCl 150 min before the sampling; the concentrations of the drug are 0.12 and 1.22 micrograms/mL for blood and urine, respectively. SN - 0021-9665 UR - https://www.unboundmedicine.com/medline/citation/9172412/Simple_analysis_of_diphenylmethane_antihistaminics_and_their_analogues_in_bodily_fluids_by_headspace_solid_phase_microextraction_capillary_gas_chromatography_ L2 - https://academic.oup.com/chromsci/article-lookup/doi/10.1093/chromsci/35.6.275 DB - PRIME DP - Unbound Medicine ER -