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Local treatment of venous ulcers with tissue type plasminogen activator containing ointment.
Vasa. 1997 May; 26(2):81-4.VASA

Abstract

BACKGROUND

The pathogenesis of venous leg ulcers is still not known. One hypothesis states that pericapillary fibrin cuffs might play an important role. These fibrin cuffs might not be broken down because of an inadequate fibrinolytic activity.

PATIENTS AND METHODS

To stimulate fibrinolysis, tissue type plasminogen activator (t-PA) containing ointment was applied over 12 weeks on chronic venous leg ulcers of six patients. Three of the six ulcers healed within this period. Biopsy specimens for immunofluorescence studies were taken from the ulcer base and margin before and at the end of treatment and, if the ulcer had healed, from the healed area.

RESULTS

Deposition of pericapillary fibrin was seen around the capillaries of all investigated ulcers at the start of the study. Pericapillary fibrin was still present with nearly undiminished intensity at the end of the study even though 3 of the ulcers healed.

CONCLUSION

It is most likely that the healing of these ulcers was not improved by the fibrinolytic activity of t-PA, but caused by other wound healing properties of t-PA.

Authors+Show Affiliations

Department of Dermatology, Hospital Eemland, Amersfoort.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9174382

Citation

Zeegelaar, J E., et al. "Local Treatment of Venous Ulcers With Tissue Type Plasminogen Activator Containing Ointment." VASA. Zeitschrift Fur Gefasskrankheiten, vol. 26, no. 2, 1997, pp. 81-4.
Zeegelaar JE, Verheijen JH, Kerckhaert JA, et al. Local treatment of venous ulcers with tissue type plasminogen activator containing ointment. Vasa. 1997;26(2):81-4.
Zeegelaar, J. E., Verheijen, J. H., Kerckhaert, J. A., Jankowski, I., & Faber, W. R. (1997). Local treatment of venous ulcers with tissue type plasminogen activator containing ointment. VASA. Zeitschrift Fur Gefasskrankheiten, 26(2), 81-4.
Zeegelaar JE, et al. Local Treatment of Venous Ulcers With Tissue Type Plasminogen Activator Containing Ointment. Vasa. 1997;26(2):81-4. PubMed PMID: 9174382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local treatment of venous ulcers with tissue type plasminogen activator containing ointment. AU - Zeegelaar,J E, AU - Verheijen,J H, AU - Kerckhaert,J A, AU - Jankowski,I, AU - Faber,W R, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 81 EP - 4 JF - VASA. Zeitschrift fur Gefasskrankheiten JO - Vasa VL - 26 IS - 2 N2 - BACKGROUND: The pathogenesis of venous leg ulcers is still not known. One hypothesis states that pericapillary fibrin cuffs might play an important role. These fibrin cuffs might not be broken down because of an inadequate fibrinolytic activity. PATIENTS AND METHODS: To stimulate fibrinolysis, tissue type plasminogen activator (t-PA) containing ointment was applied over 12 weeks on chronic venous leg ulcers of six patients. Three of the six ulcers healed within this period. Biopsy specimens for immunofluorescence studies were taken from the ulcer base and margin before and at the end of treatment and, if the ulcer had healed, from the healed area. RESULTS: Deposition of pericapillary fibrin was seen around the capillaries of all investigated ulcers at the start of the study. Pericapillary fibrin was still present with nearly undiminished intensity at the end of the study even though 3 of the ulcers healed. CONCLUSION: It is most likely that the healing of these ulcers was not improved by the fibrinolytic activity of t-PA, but caused by other wound healing properties of t-PA. SN - 0301-1526 UR - https://www.unboundmedicine.com/medline/citation/9174382/Local_treatment_of_venous_ulcers_with_tissue_type_plasminogen_activator_containing_ointment_ DB - PRIME DP - Unbound Medicine ER -