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A twin study of polycystic ovary syndrome and lipids.
Gynecol Endocrinol 1997; 11(2):111-7GE

Abstract

Our objective was to assess the relative contribution of genetic and environmental factors (particularly androgens) on circulating levels of lipid fractions and to determine the effect, if any, of polycystic ovary syndrome (PCOS) on lipid fractions. The study was carried out in the outpatient clinic of the Royal Hospital for Women, Paddington, Sydney, Australia. A group of 19 monozygotic (MZ) and 15 dizygotic (DZ) twin pairs was identified from the National Twin Register. Ultrasound clinical and biochemical parameters were used to define polycystic ovaries. Serum androgen and lipid fractions were also measured. Eleven pairs of twins (five MZ, six DZ) were scan discordant (i.e. one twin had polycystic ovaries and the co-twin did not). Serum levels of the lipoprotein fractions in twins with polycystic ovaries were not significantly different from the levels found for their co-twins with normal ovaries. There were no significant correlations between androgen-related hormones and any of the lipid measurements. Body mass index (BMI) was positively correlated with triglycerides and lipoprotein (a), and negatively correlated with high-density lipoprotein cholesterol (HDL-C). Sex hormone-binding globulin (SHBG) levels were negatively correlated with triglycerides and lipoprotein (a) and positively associated with HDL-C. Fasting insulin levels were significantly correlated with triglycerides and negatively with HDL-C. The MZ intraclass correlation exceeded that of the DZ twin pairs for all the lipid variables measured. The heritability estimates for lipoprotein (a), apolipoprotein B, total cholesterol and HDL-C were 0.95, 0.56, 0.48 and 0.54, respectively. However, the intraclass correlation coefficient for triglycerides was not significantly different between MZ and DZ twins, but maximum likelihood analysis indicated that at least 10% of the variance of the circulating triglyceride concentration is determined by genetic factors. We conclude that twins discordant for the PCOS do not have significantly different lipid fractions.

Authors+Show Affiliations

Frank Rundle House, Royal Hospital for Women, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

9174852

Citation

Jahanfar, S, et al. "A Twin Study of Polycystic Ovary Syndrome and Lipids." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 11, no. 2, 1997, pp. 111-7.
Jahanfar S, Eden JA, Nguyen T, et al. A twin study of polycystic ovary syndrome and lipids. Gynecol Endocrinol. 1997;11(2):111-7.
Jahanfar, S., Eden, J. A., Nguyen, T., Wang, X. L., & Wilcken, D. E. (1997). A twin study of polycystic ovary syndrome and lipids. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 11(2), pp. 111-7.
Jahanfar S, et al. A Twin Study of Polycystic Ovary Syndrome and Lipids. Gynecol Endocrinol. 1997;11(2):111-7. PubMed PMID: 9174852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A twin study of polycystic ovary syndrome and lipids. AU - Jahanfar,S, AU - Eden,J A, AU - Nguyen,T, AU - Wang,X L, AU - Wilcken,D E, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 111 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 11 IS - 2 N2 - Our objective was to assess the relative contribution of genetic and environmental factors (particularly androgens) on circulating levels of lipid fractions and to determine the effect, if any, of polycystic ovary syndrome (PCOS) on lipid fractions. The study was carried out in the outpatient clinic of the Royal Hospital for Women, Paddington, Sydney, Australia. A group of 19 monozygotic (MZ) and 15 dizygotic (DZ) twin pairs was identified from the National Twin Register. Ultrasound clinical and biochemical parameters were used to define polycystic ovaries. Serum androgen and lipid fractions were also measured. Eleven pairs of twins (five MZ, six DZ) were scan discordant (i.e. one twin had polycystic ovaries and the co-twin did not). Serum levels of the lipoprotein fractions in twins with polycystic ovaries were not significantly different from the levels found for their co-twins with normal ovaries. There were no significant correlations between androgen-related hormones and any of the lipid measurements. Body mass index (BMI) was positively correlated with triglycerides and lipoprotein (a), and negatively correlated with high-density lipoprotein cholesterol (HDL-C). Sex hormone-binding globulin (SHBG) levels were negatively correlated with triglycerides and lipoprotein (a) and positively associated with HDL-C. Fasting insulin levels were significantly correlated with triglycerides and negatively with HDL-C. The MZ intraclass correlation exceeded that of the DZ twin pairs for all the lipid variables measured. The heritability estimates for lipoprotein (a), apolipoprotein B, total cholesterol and HDL-C were 0.95, 0.56, 0.48 and 0.54, respectively. However, the intraclass correlation coefficient for triglycerides was not significantly different between MZ and DZ twins, but maximum likelihood analysis indicated that at least 10% of the variance of the circulating triglyceride concentration is determined by genetic factors. We conclude that twins discordant for the PCOS do not have significantly different lipid fractions. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/9174852/A_twin_study_of_polycystic_ovary_syndrome_and_lipids_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513599709152521 DB - PRIME DP - Unbound Medicine ER -