Tags

Type your tag names separated by a space and hit enter

Thioredoxin reductase activity is decreased by selenium deficiency.
Biochem Biophys Res Commun 1997; 234(2):293-5BB

Abstract

Animal thioredoxin reductase is a selenoprotein. In this study, thioredoxin reductase activities in liver, kidney, and brain have been compared in rats fed selenium-deficient and control diets for 14 weeks following weaning. Selenium deficiency caused a decrease in thioredoxin reductase activity from control to 4.5% in liver and 11% in kidney. However, brain thioredoxin reductase activity was not affected by selenium deficiency of this severity. Gold inhibited thioredoxin reductase activity in the liver in a manner typical of its effect on selenoenzymes. Repletion of selenium-deficient rats with injections of selenium caused thioredoxin reductase activity to increase more rapidly in the liver than glutathione peroxidase activity but more slowly than selenoprotein P. These results indicate that thioredoxin reductase activity in liver and kidney is sensitive to selenium nutritional status but that brain thioredoxin reductase activity is less sensitive.

Authors+Show Affiliations

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9177261

Citation

Hill, K E., et al. "Thioredoxin Reductase Activity Is Decreased By Selenium Deficiency." Biochemical and Biophysical Research Communications, vol. 234, no. 2, 1997, pp. 293-5.
Hill KE, McCollum GW, Boeglin ME, et al. Thioredoxin reductase activity is decreased by selenium deficiency. Biochem Biophys Res Commun. 1997;234(2):293-5.
Hill, K. E., McCollum, G. W., Boeglin, M. E., & Burk, R. F. (1997). Thioredoxin reductase activity is decreased by selenium deficiency. Biochemical and Biophysical Research Communications, 234(2), pp. 293-5.
Hill KE, et al. Thioredoxin Reductase Activity Is Decreased By Selenium Deficiency. Biochem Biophys Res Commun. 1997 May 19;234(2):293-5. PubMed PMID: 9177261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thioredoxin reductase activity is decreased by selenium deficiency. AU - Hill,K E, AU - McCollum,G W, AU - Boeglin,M E, AU - Burk,R F, PY - 1997/5/19/pubmed PY - 1997/5/19/medline PY - 1997/5/19/entrez SP - 293 EP - 5 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 234 IS - 2 N2 - Animal thioredoxin reductase is a selenoprotein. In this study, thioredoxin reductase activities in liver, kidney, and brain have been compared in rats fed selenium-deficient and control diets for 14 weeks following weaning. Selenium deficiency caused a decrease in thioredoxin reductase activity from control to 4.5% in liver and 11% in kidney. However, brain thioredoxin reductase activity was not affected by selenium deficiency of this severity. Gold inhibited thioredoxin reductase activity in the liver in a manner typical of its effect on selenoenzymes. Repletion of selenium-deficient rats with injections of selenium caused thioredoxin reductase activity to increase more rapidly in the liver than glutathione peroxidase activity but more slowly than selenoprotein P. These results indicate that thioredoxin reductase activity in liver and kidney is sensitive to selenium nutritional status but that brain thioredoxin reductase activity is less sensitive. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/9177261/Thioredoxin_reductase_activity_is_decreased_by_selenium_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(97)96618-3 DB - PRIME DP - Unbound Medicine ER -