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Dental abnormalities in children treated for acute lymphoblastic leukemia.
Leukemia. 1997 Jun; 11(6):792-6.L

Abstract

The purpose of this study was to define the therapy-associated dental abnormalities in survivors of acute lymphoblastic leukemia (ALL). We reviewed the clinical records and panoramic radiographs of 423 survivors of ALL who were treated on one of four consecutive protocols (1975-1991). Dental abnormalities included root stunting, microdontia, hypodontia, taurodontia (enlarged pulp chambers), and over-retention of primary teeth. The frequency of these factors was determined in relation to age at initiation of treatment (< or = 8 years vs > 8 years), addition of cranial irradiation, and chemotherapeutic protocol. A total of 423 patients met the study criteria. The abnormalities comprised root stunting in 24.4% (n = 103), microdontia in 18.9% (n = 80), hypodontia in 8.5% (n = 36), taurodontia in 5.9% (n = 25), and over-retention of primary dentition in 4.0% (n = 17). Patients who were < or = 8 years old at diagnosis or who received cranial irradiation therapy developed more dental abnormalities than did those > 8 years and those who did not receive cranial irradiation (42 vs 32%). Survivors of childhood ALL often have dental abnormalities that may affect their quality of life. Dental evaluation at diagnosis and frequent follow-up may help to ensure appropriate preventive measures and minimize dental and periodontal disease.

Authors+Show Affiliations

Department of Diagnostic Imaging, St Jude's Children's Research Hospital, and University of Tennessee, Memphis 38101, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9177429

Citation

Kaste, S C., et al. "Dental Abnormalities in Children Treated for Acute Lymphoblastic Leukemia." Leukemia, vol. 11, no. 6, 1997, pp. 792-6.
Kaste SC, Hopkins KP, Jones D, et al. Dental abnormalities in children treated for acute lymphoblastic leukemia. Leukemia. 1997;11(6):792-6.
Kaste, S. C., Hopkins, K. P., Jones, D., Crom, D., Greenwald, C. A., & Santana, V. M. (1997). Dental abnormalities in children treated for acute lymphoblastic leukemia. Leukemia, 11(6), 792-6.
Kaste SC, et al. Dental Abnormalities in Children Treated for Acute Lymphoblastic Leukemia. Leukemia. 1997;11(6):792-6. PubMed PMID: 9177429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dental abnormalities in children treated for acute lymphoblastic leukemia. AU - Kaste,S C, AU - Hopkins,K P, AU - Jones,D, AU - Crom,D, AU - Greenwald,C A, AU - Santana,V M, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 792 EP - 6 JF - Leukemia JO - Leukemia VL - 11 IS - 6 N2 - The purpose of this study was to define the therapy-associated dental abnormalities in survivors of acute lymphoblastic leukemia (ALL). We reviewed the clinical records and panoramic radiographs of 423 survivors of ALL who were treated on one of four consecutive protocols (1975-1991). Dental abnormalities included root stunting, microdontia, hypodontia, taurodontia (enlarged pulp chambers), and over-retention of primary teeth. The frequency of these factors was determined in relation to age at initiation of treatment (< or = 8 years vs > 8 years), addition of cranial irradiation, and chemotherapeutic protocol. A total of 423 patients met the study criteria. The abnormalities comprised root stunting in 24.4% (n = 103), microdontia in 18.9% (n = 80), hypodontia in 8.5% (n = 36), taurodontia in 5.9% (n = 25), and over-retention of primary dentition in 4.0% (n = 17). Patients who were < or = 8 years old at diagnosis or who received cranial irradiation therapy developed more dental abnormalities than did those > 8 years and those who did not receive cranial irradiation (42 vs 32%). Survivors of childhood ALL often have dental abnormalities that may affect their quality of life. Dental evaluation at diagnosis and frequent follow-up may help to ensure appropriate preventive measures and minimize dental and periodontal disease. SN - 0887-6924 UR - https://www.unboundmedicine.com/medline/citation/9177429/Dental_abnormalities_in_children_treated_for_acute_lymphoblastic_leukemia_ L2 - http://dx.doi.org/10.1038/sj.leu.2400670 DB - PRIME DP - Unbound Medicine ER -