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Endometriosis and infertility: new concepts.

Abstract

Endometriosis is a common gynecological disorder with varied symptomatology including chronic pelvic pain, dysmenorrhea, and infertility. The association of endometriosis and infertility has been recognized for years, although definite evidence of causality still eludes us. In this review, we will explore three general concepts that enhance our understanding of the cellular and molecular interactions contributing to the pathophysiology of this disorder and that have steered current research in endometriosis. First, we review evidence of a local peritoneal inflammatory process, supported by the findings of elevated cytokine and growth factor concentrations in peritoneal fluid of affected patients. Second, we propose a role for angiogenic factors in the establishment of ectopic implants. Third, we review evidence for biochemical differences of eutopic and ectopic endometrium in endometriosis patients, which may contribute to both the pathogenesis and sequelae of this important disorder. Through information derived from these research efforts, we hope to develop better therapeutic interventions as adjunctive or alternative therapies to our current medical and surgical armamentarium.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143-0556, USA.

    Source

    Obstetrical & gynecological survey 52:6 1997 Jun pg 365-71

    MeSH

    Endometriosis
    Female
    Humans
    Infertility, Female

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    9178310

    Citation

    Ryan, I P., and R N. Taylor. "Endometriosis and Infertility: New Concepts." Obstetrical & Gynecological Survey, vol. 52, no. 6, 1997, pp. 365-71.
    Ryan IP, Taylor RN. Endometriosis and infertility: new concepts. Obstet Gynecol Surv. 1997;52(6):365-71.
    Ryan, I. P., & Taylor, R. N. (1997). Endometriosis and infertility: new concepts. Obstetrical & Gynecological Survey, 52(6), pp. 365-71.
    Ryan IP, Taylor RN. Endometriosis and Infertility: New Concepts. Obstet Gynecol Surv. 1997;52(6):365-71. PubMed PMID: 9178310.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endometriosis and infertility: new concepts. AU - Ryan,I P, AU - Taylor,R N, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 365 EP - 71 JF - Obstetrical & gynecological survey JO - Obstet Gynecol Surv VL - 52 IS - 6 N2 - Endometriosis is a common gynecological disorder with varied symptomatology including chronic pelvic pain, dysmenorrhea, and infertility. The association of endometriosis and infertility has been recognized for years, although definite evidence of causality still eludes us. In this review, we will explore three general concepts that enhance our understanding of the cellular and molecular interactions contributing to the pathophysiology of this disorder and that have steered current research in endometriosis. First, we review evidence of a local peritoneal inflammatory process, supported by the findings of elevated cytokine and growth factor concentrations in peritoneal fluid of affected patients. Second, we propose a role for angiogenic factors in the establishment of ectopic implants. Third, we review evidence for biochemical differences of eutopic and ectopic endometrium in endometriosis patients, which may contribute to both the pathogenesis and sequelae of this important disorder. Through information derived from these research efforts, we hope to develop better therapeutic interventions as adjunctive or alternative therapies to our current medical and surgical armamentarium. SN - 0029-7828 UR - https://www.unboundmedicine.com/medline/citation/9178310/Endometriosis_and_infertility:_new_concepts_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9178310.ui DB - PRIME DP - Unbound Medicine ER -