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Modification of oral contraceptive relationships on breast cancer risk by selected factors among younger women.

Abstract

In a case-control study of 1647 breast cancer cases and 1501 population controls under 45 years of age, potential modifying effects of other risk factors on the relationship of oral contraceptives to breast cancer were examined. Among the total series of study subjects, the relationship of extended pill usage was greater in non-white than white women. Oral contraceptive associations, however, did not appear to be substantially modified by other risk factors, including parity, body size, or family history of breast cancer (apart from a somewhat enhanced relationship among subjects who reported a sister with breast cancer. Further, oral contraceptive relationships did not vary by a history of benign breast disease, although the majority of subjects began pill usage prior to the development of benign breast disease. Among the women under the age of 35, in whom oral contraceptive relationships were heightened (over a twofold excess risk for use of 5 years or longer), pill relationships were less modified by race than in the total series. Although among these younger subjects there was no effect of pill usage in heavy women, and an enhanced relationship among heavier consumers of alcoholic beverages, these interactive effects were not statistically significant. The findings of this study generally support no substantial variation in oral contraceptive relationships by other breast cancer risk factors, although some further attention might be warranted regarding possible modifying effects of race, body size, type of relative with breast cancer, and alcohol consumption.

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  • Authors+Show Affiliations

    ,

    Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA. brinton@epndce.nci.nih.gov

    , , , ,

    Source

    Contraception 55:4 1997 Apr pg 197-203

    MeSH

    Adult
    African Continental Ancestry Group
    Biopsy
    Body Mass Index
    Breast Neoplasms
    Case-Control Studies
    Continental Population Groups
    Contraceptives, Oral
    European Continental Ancestry Group
    Female
    Humans
    Menarche
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    9179450

    Citation

    Brinton, L A., et al. "Modification of Oral Contraceptive Relationships On Breast Cancer Risk By Selected Factors Among Younger Women." Contraception, vol. 55, no. 4, 1997, pp. 197-203.
    Brinton LA, Gammon MD, Malone KE, et al. Modification of oral contraceptive relationships on breast cancer risk by selected factors among younger women. Contraception. 1997;55(4):197-203.
    Brinton, L. A., Gammon, M. D., Malone, K. E., Schoenberg, J. B., Daling, J. R., & Coates, R. J. (1997). Modification of oral contraceptive relationships on breast cancer risk by selected factors among younger women. Contraception, 55(4), pp. 197-203.
    Brinton LA, et al. Modification of Oral Contraceptive Relationships On Breast Cancer Risk By Selected Factors Among Younger Women. Contraception. 1997;55(4):197-203. PubMed PMID: 9179450.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modification of oral contraceptive relationships on breast cancer risk by selected factors among younger women. AU - Brinton,L A, AU - Gammon,M D, AU - Malone,K E, AU - Schoenberg,J B, AU - Daling,J R, AU - Coates,R J, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez KW - Americas KW - Blacks--women KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Cultural Background KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Ethnic Groups KW - Evaluation KW - Family Planning KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Population KW - Population Characteristics KW - Research Methodology KW - Research Report KW - Risk Assessment KW - Studies KW - United States KW - Whites--women SP - 197 EP - 203 JF - Contraception JO - Contraception VL - 55 IS - 4 N2 - In a case-control study of 1647 breast cancer cases and 1501 population controls under 45 years of age, potential modifying effects of other risk factors on the relationship of oral contraceptives to breast cancer were examined. Among the total series of study subjects, the relationship of extended pill usage was greater in non-white than white women. Oral contraceptive associations, however, did not appear to be substantially modified by other risk factors, including parity, body size, or family history of breast cancer (apart from a somewhat enhanced relationship among subjects who reported a sister with breast cancer. Further, oral contraceptive relationships did not vary by a history of benign breast disease, although the majority of subjects began pill usage prior to the development of benign breast disease. Among the women under the age of 35, in whom oral contraceptive relationships were heightened (over a twofold excess risk for use of 5 years or longer), pill relationships were less modified by race than in the total series. Although among these younger subjects there was no effect of pill usage in heavy women, and an enhanced relationship among heavier consumers of alcoholic beverages, these interactive effects were not statistically significant. The findings of this study generally support no substantial variation in oral contraceptive relationships by other breast cancer risk factors, although some further attention might be warranted regarding possible modifying effects of race, body size, type of relative with breast cancer, and alcohol consumption. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/9179450/Modification_of_oral_contraceptive_relationships_on_breast_cancer_risk_by_selected_factors_among_younger_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010782497000127 DB - PRIME DP - Unbound Medicine ER -