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Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Drug Alcohol Depend. 1997 Apr 14; 45(1-2):39-45.DA

Abstract

The endogenous ligand for the cannabinoid receptor, arachidonylethanolamide (anandamide), has been shown to produce antinociception using the tail-flick test following intrathecal administration. Anandamide was administered i.p. (40 mg kg) to mice four times per day for 3 days. Tolerance developed to anandamide: the ED50 for anandamide (i.t.) was shifted from 40 (26-61) to 139 (79-248) micrograms/mouse. Anandamide-tolerant mice were cross-tolerant to delta 9-THC and CP55,940, but not cross-tolerant to mu-, delta- or kappa- opioids, including dynorphins. Conversely, delta 9-THC-tolerant mice are cross-tolerant to anandamide, CP55,940 and kappa agonists. Our data indicate that anandamide and delta 9-THC differ in the mechanisms by which they induce tolerance, in particular the interaction with endogenous dynorphinergic systems.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 980613, USA.

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9179505

Citation

Welch, S P.. "Characterization of Anandamide-induced Tolerance: Comparison to Delta 9-THC-induced Interactions With Dynorphinergic Systems." Drug and Alcohol Dependence, vol. 45, no. 1-2, 1997, pp. 39-45.
Welch SP. Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. Drug Alcohol Depend. 1997;45(1-2):39-45.
Welch, S. P. (1997). Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. Drug and Alcohol Dependence, 45(1-2), 39-45.
Welch SP. Characterization of Anandamide-induced Tolerance: Comparison to Delta 9-THC-induced Interactions With Dynorphinergic Systems. Drug Alcohol Depend. 1997 Apr 14;45(1-2):39-45. PubMed PMID: 9179505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. A1 - Welch,S P, PY - 1997/4/14/pubmed PY - 1997/4/14/medline PY - 1997/4/14/entrez SP - 39 EP - 45 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 45 IS - 1-2 N2 - The endogenous ligand for the cannabinoid receptor, arachidonylethanolamide (anandamide), has been shown to produce antinociception using the tail-flick test following intrathecal administration. Anandamide was administered i.p. (40 mg kg) to mice four times per day for 3 days. Tolerance developed to anandamide: the ED50 for anandamide (i.t.) was shifted from 40 (26-61) to 139 (79-248) micrograms/mouse. Anandamide-tolerant mice were cross-tolerant to delta 9-THC and CP55,940, but not cross-tolerant to mu-, delta- or kappa- opioids, including dynorphins. Conversely, delta 9-THC-tolerant mice are cross-tolerant to anandamide, CP55,940 and kappa agonists. Our data indicate that anandamide and delta 9-THC differ in the mechanisms by which they induce tolerance, in particular the interaction with endogenous dynorphinergic systems. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/9179505/Characterization_of_anandamide_induced_tolerance:_comparison_to_delta_9_THC_induced_interactions_with_dynorphinergic_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(97)01342-2 DB - PRIME DP - Unbound Medicine ER -