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Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia.
J Med Virol. 1997 Jun; 52(2):143-8.JM

Abstract

We studied the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among 112 patients with liver disease and 121 blood donors in Ulaanbaatar, Mongolia. Reverse transcription and polymerase chain reaction were employed to detect GBV-C/HGV RNA using the specific primers derived from the 5'-untranslated region (5'-UTR) of the GBV-C/HGV genome. Nucleotide sequences of all positive samples for GBV-C/HGV RNA were determined. The sequences were analyzed by a molecular evolutionary method. Twenty-five (10.7%) of 233 people were positive for GBV-C/HGV RNA. Eight (6.6%), 11 (9.1%), and 30 (24.8%) blood donors were positive for GBV-C/HGV RNA, HBsAg, and anti-HCV, respectively, although 17 (15.2%), 65 (58.0%), and 64 (54.5%) patients with liver disease were positive for each viral marker. The prevalences of GBV-C/HGV RNA, HBV, and HCV in the patients were significantly higher than those in blood donors (P < 0.05). There was no significant difference in the prevalence of anti-HCV among people with and without GBV-C/HGV RNA, while the prevalence of HBsAg among people with GBV-C/HGV RNA was significantly higher than among those without GBV-C/HGV RNA (P < 0.05). The molecular evolutionary tree showed that GBV-C/HGV was a heterogeneous virus and all strains could be divided into 2 types. One is the same phylogenetic type as HGV, and the other is a new type that is different from GBV-C and HGV.

Authors+Show Affiliations

Second Department of Medicine, Nagoya City University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9179759

Citation

Kondo, Y, et al. "Prevalence and Molecular Epidemiology of GB Virus C/hepatitis G Virus Infection in Mongolia." Journal of Medical Virology, vol. 52, no. 2, 1997, pp. 143-8.
Kondo Y, Mizokami M, Nakano T, et al. Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. J Med Virol. 1997;52(2):143-8.
Kondo, Y., Mizokami, M., Nakano, T., Kato, T., Ueda, R., Mukaide, M., Hikiji, K., Ishida, T., Dorjsuren, D., Dashnyam, B., & Oyunsuren, T. (1997). Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. Journal of Medical Virology, 52(2), 143-8.
Kondo Y, et al. Prevalence and Molecular Epidemiology of GB Virus C/hepatitis G Virus Infection in Mongolia. J Med Virol. 1997;52(2):143-8. PubMed PMID: 9179759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. AU - Kondo,Y, AU - Mizokami,M, AU - Nakano,T, AU - Kato,T, AU - Ueda,R, AU - Mukaide,M, AU - Hikiji,K, AU - Ishida,T, AU - Dorjsuren,D, AU - Dashnyam,B, AU - Oyunsuren,T, PY - 1997/6/1/pubmed PY - 2000/6/20/medline PY - 1997/6/1/entrez SP - 143 EP - 8 JF - Journal of medical virology JO - J. Med. Virol. VL - 52 IS - 2 N2 - We studied the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among 112 patients with liver disease and 121 blood donors in Ulaanbaatar, Mongolia. Reverse transcription and polymerase chain reaction were employed to detect GBV-C/HGV RNA using the specific primers derived from the 5'-untranslated region (5'-UTR) of the GBV-C/HGV genome. Nucleotide sequences of all positive samples for GBV-C/HGV RNA were determined. The sequences were analyzed by a molecular evolutionary method. Twenty-five (10.7%) of 233 people were positive for GBV-C/HGV RNA. Eight (6.6%), 11 (9.1%), and 30 (24.8%) blood donors were positive for GBV-C/HGV RNA, HBsAg, and anti-HCV, respectively, although 17 (15.2%), 65 (58.0%), and 64 (54.5%) patients with liver disease were positive for each viral marker. The prevalences of GBV-C/HGV RNA, HBV, and HCV in the patients were significantly higher than those in blood donors (P < 0.05). There was no significant difference in the prevalence of anti-HCV among people with and without GBV-C/HGV RNA, while the prevalence of HBsAg among people with GBV-C/HGV RNA was significantly higher than among those without GBV-C/HGV RNA (P < 0.05). The molecular evolutionary tree showed that GBV-C/HGV was a heterogeneous virus and all strains could be divided into 2 types. One is the same phylogenetic type as HGV, and the other is a new type that is different from GBV-C and HGV. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/9179759/Prevalence_and_molecular_epidemiology_of_GB_virus_C/hepatitis_G_virus_infection_in_Mongolia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0146-6615&amp;date=1997&amp;volume=52&amp;issue=2&amp;spage=143 DB - PRIME DP - Unbound Medicine ER -