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Family history and the risk of breast cancer: a systematic review and meta-analysis.
Int J Cancer. 1997 May 29; 71(5):800-9.IJ

Abstract

An increased risk of breast cancer in women with a family history of breast cancer has been demonstrated by many studies using a variety of study designs. However, the extent of this risk varies according to the nature of the family history (type of relative affected, age at which relative developed breast cancer and number of relatives affected) and may also vary according to age of the individual. The aim of our study was to identify all the published studies which have quantified the risk of breast cancer associated with a family history of the disease, and to summarise the evidence from these studies, with particular emphasis on age-specific risks according to subject and relative age. Seventy-four published studies were identified. The pooled estimate of relative risk (RR) associated with various family histories was as follows: any relative, RR = 1.9 (95% CI, 1.7-2.0); a first-degree relative, RR = 2.1 (CI = 2.0, 2.2); mother, RR = 2.0 (CI = 1.8, 2.1); sister, RR = 2.3 (CI = 2.1, 2.4); daughter, RR = 1.8 (CI = 1.6, 2.0); mother and sister, RR = 3.6 (CI = 2.5, 5.0); and a second-degree relative, RR = 1.5 (CI = 1.4, 1.6). Risks were increased in subjects under age 50 and when the relative had been diagnosed before age 50.

Authors+Show Affiliations

Institute of Public Health, Cambridge, UK. pp10001@medschl.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

9180149

Citation

Pharoah, P D., et al. "Family History and the Risk of Breast Cancer: a Systematic Review and Meta-analysis." International Journal of Cancer, vol. 71, no. 5, 1997, pp. 800-9.
Pharoah PD, Day NE, Duffy S, et al. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer. 1997;71(5):800-9.
Pharoah, P. D., Day, N. E., Duffy, S., Easton, D. F., & Ponder, B. A. (1997). Family history and the risk of breast cancer: a systematic review and meta-analysis. International Journal of Cancer, 71(5), 800-9.
Pharoah PD, et al. Family History and the Risk of Breast Cancer: a Systematic Review and Meta-analysis. Int J Cancer. 1997 May 29;71(5):800-9. PubMed PMID: 9180149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history and the risk of breast cancer: a systematic review and meta-analysis. AU - Pharoah,P D, AU - Day,N E, AU - Duffy,S, AU - Easton,D F, AU - Ponder,B A, PY - 1997/5/29/pubmed PY - 2000/6/20/medline PY - 1997/5/29/entrez SP - 800 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 71 IS - 5 N2 - An increased risk of breast cancer in women with a family history of breast cancer has been demonstrated by many studies using a variety of study designs. However, the extent of this risk varies according to the nature of the family history (type of relative affected, age at which relative developed breast cancer and number of relatives affected) and may also vary according to age of the individual. The aim of our study was to identify all the published studies which have quantified the risk of breast cancer associated with a family history of the disease, and to summarise the evidence from these studies, with particular emphasis on age-specific risks according to subject and relative age. Seventy-four published studies were identified. The pooled estimate of relative risk (RR) associated with various family histories was as follows: any relative, RR = 1.9 (95% CI, 1.7-2.0); a first-degree relative, RR = 2.1 (CI = 2.0, 2.2); mother, RR = 2.0 (CI = 1.8, 2.1); sister, RR = 2.3 (CI = 2.1, 2.4); daughter, RR = 1.8 (CI = 1.6, 2.0); mother and sister, RR = 3.6 (CI = 2.5, 5.0); and a second-degree relative, RR = 1.5 (CI = 1.4, 1.6). Risks were increased in subjects under age 50 and when the relative had been diagnosed before age 50. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/9180149/Family_history_and_the_risk_of_breast_cancer:_a_systematic_review_and_meta_analysis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1997&volume=71&issue=5&spage=800 DB - PRIME DP - Unbound Medicine ER -