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Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions.
J Infect Dis. 1997 Jun; 175(6):1324-32.JI

Abstract

The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS.

Authors+Show Affiliations

Department of Microbiology and Immunology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9180170

Citation

Webster-Cyriaque, J, et al. "Epstein-Barr Virus and Human Herpesvirus 8 Prevalence in Human Immunodeficiency Virus-associated Oral Mucosal Lesions." The Journal of Infectious Diseases, vol. 175, no. 6, 1997, pp. 1324-32.
Webster-Cyriaque J, Edwards RH, Quinlivan EB, et al. Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions. J Infect Dis. 1997;175(6):1324-32.
Webster-Cyriaque, J., Edwards, R. H., Quinlivan, E. B., Patton, L., Wohl, D., & Raab-Traub, N. (1997). Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions. The Journal of Infectious Diseases, 175(6), 1324-32.
Webster-Cyriaque J, et al. Epstein-Barr Virus and Human Herpesvirus 8 Prevalence in Human Immunodeficiency Virus-associated Oral Mucosal Lesions. J Infect Dis. 1997;175(6):1324-32. PubMed PMID: 9180170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epstein-Barr virus and human herpesvirus 8 prevalence in human immunodeficiency virus-associated oral mucosal lesions. AU - Webster-Cyriaque,J, AU - Edwards,R H, AU - Quinlivan,E B, AU - Patton,L, AU - Wohl,D, AU - Raab-Traub,N, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 1324 EP - 32 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 175 IS - 6 N2 - The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/9180170/Epstein_Barr_virus_and_human_herpesvirus_8_prevalence_in_human_immunodeficiency_virus_associated_oral_mucosal_lesions_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/516463 DB - PRIME DP - Unbound Medicine ER -