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New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease.
Atherosclerosis. 1997 May; 131(1):43-8.A

Abstract

It is known that the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of vascular endothelial cells is closely related to the formation of early atherosclerotic lesions. In this study, serum soluble ICAM-1(sICAM-1) and soluble VCAM-1(sVCAM-1) were determined by sandwich ELISA both in normal healthy individuals (n = 114) and in patients with hypercholesterolemia (HC, n = 112) or ischemic heart disease (IHD, n = 38) to clarify the significance of the soluble forms of the adhesion molecules in the development of atherosclerotic diseases. IHD patients, not HC patients, showed significant elevation of sICAM-1, but not of sVCAM-1, compared with controls in age and sex-matched subjects. In addition, multiple linear regression analysis showed that sICAM-1 was correlated only to the presence of IHD but not to age and lipids. Multiple logistic regression analysis revealed that sICAM-1 was the most powerful independent predictor of the presence of IHD. On the other hand, sVCAM-1, not sICAM-1, was positively correlated to age. Multiple linear regression analysis showed that age was the most powerful independent predictor of the level of sVCAM-1. These data suggest that sICAM-1 and sVCAM-1 are useful as indices of clinical manifestations of atherosclerosis and aging, respectively.

Authors+Show Affiliations

The Second Department of Internal Medicine, School of Medicine, Chiba University, Chuo-ku, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9180243

Citation

Morisaki, N, et al. "New Indices of Ischemic Heart Disease and Aging: Studies On the Serum Levels of Soluble Intercellular Adhesion Molecule-1 (ICAM-1) and Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) in Patients With Hypercholesterolemia and Ischemic Heart Disease." Atherosclerosis, vol. 131, no. 1, 1997, pp. 43-8.
Morisaki N, Saito I, Tamura K, et al. New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis. 1997;131(1):43-8.
Morisaki, N., Saito, I., Tamura, K., Tashiro, J., Masuda, M., Kanzaki, T., Watanabe, S., Masuda, Y., & Saito, Y. (1997). New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis, 131(1), 43-8.
Morisaki N, et al. New Indices of Ischemic Heart Disease and Aging: Studies On the Serum Levels of Soluble Intercellular Adhesion Molecule-1 (ICAM-1) and Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) in Patients With Hypercholesterolemia and Ischemic Heart Disease. Atherosclerosis. 1997;131(1):43-8. PubMed PMID: 9180243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. AU - Morisaki,N, AU - Saito,I, AU - Tamura,K, AU - Tashiro,J, AU - Masuda,M, AU - Kanzaki,T, AU - Watanabe,S, AU - Masuda,Y, AU - Saito,Y, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 43 EP - 8 JF - Atherosclerosis JO - Atherosclerosis VL - 131 IS - 1 N2 - It is known that the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of vascular endothelial cells is closely related to the formation of early atherosclerotic lesions. In this study, serum soluble ICAM-1(sICAM-1) and soluble VCAM-1(sVCAM-1) were determined by sandwich ELISA both in normal healthy individuals (n = 114) and in patients with hypercholesterolemia (HC, n = 112) or ischemic heart disease (IHD, n = 38) to clarify the significance of the soluble forms of the adhesion molecules in the development of atherosclerotic diseases. IHD patients, not HC patients, showed significant elevation of sICAM-1, but not of sVCAM-1, compared with controls in age and sex-matched subjects. In addition, multiple linear regression analysis showed that sICAM-1 was correlated only to the presence of IHD but not to age and lipids. Multiple logistic regression analysis revealed that sICAM-1 was the most powerful independent predictor of the presence of IHD. On the other hand, sVCAM-1, not sICAM-1, was positively correlated to age. Multiple linear regression analysis showed that age was the most powerful independent predictor of the level of sVCAM-1. These data suggest that sICAM-1 and sVCAM-1 are useful as indices of clinical manifestations of atherosclerosis and aging, respectively. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/9180243/New_indices_of_ischemic_heart_disease_and_aging:_studies_on_the_serum_levels_of_soluble_intercellular_adhesion_molecule_1__ICAM_1__and_soluble_vascular_cell_adhesion_molecule_1__VCAM_1__in_patients_with_hypercholesterolemia_and_ischemic_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(97)06083-8 DB - PRIME DP - Unbound Medicine ER -