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Thromboxane A2 and related prostaglandins in airways.
Fundam Clin Pharmacol 1997; 11(1):2-18FC

Abstract

Asthma is now thought to be a chronic inflammatory disease of the airways. The roles of prostanoids, thromboxane A2 (TXA2) and the prostaglandins (PGs) in the pathogenesis and pathophysiology of asthma have fostered a wealth of studies but remain controversial. TXA2 and the bronchoconstrictor PGs, PGD2 and PGF2 alpha, are generated in greater amounts in asthmatic than in normal subjects. TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway microvascular leakage. It may participate in the thickening and the remodeling of the airway wall which may contribute to the airway hyperresponsiveness, a typical feature of asthma. Strategies for inhibition of TXA2 effects include antagonism of the TXA2 receptor (TP receptor) and inhibition of the thromboxane synthase. TP receptor antagonists could block the effects of all the bronchoconstrictor prostanoids because TXA2 as well as the bronchoconstrictor PGs act through activation of lung TP receptor. The recent development of specific and potent TP receptor antagonists and inhibitors of thromboxane synthase has provided tools to assess the role of TXA2 and broncho-constrictor PGs in the pathophysiology of asthma.

Authors+Show Affiliations

Laboratoire de Pharmacologie, CHRU Grenoble, France.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9182072

Citation

Devillier, P, and G Bessard. "Thromboxane A2 and Related Prostaglandins in Airways." Fundamental & Clinical Pharmacology, vol. 11, no. 1, 1997, pp. 2-18.
Devillier P, Bessard G. Thromboxane A2 and related prostaglandins in airways. Fundam Clin Pharmacol. 1997;11(1):2-18.
Devillier, P., & Bessard, G. (1997). Thromboxane A2 and related prostaglandins in airways. Fundamental & Clinical Pharmacology, 11(1), pp. 2-18.
Devillier P, Bessard G. Thromboxane A2 and Related Prostaglandins in Airways. Fundam Clin Pharmacol. 1997;11(1):2-18. PubMed PMID: 9182072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thromboxane A2 and related prostaglandins in airways. AU - Devillier,P, AU - Bessard,G, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 2 EP - 18 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 11 IS - 1 N2 - Asthma is now thought to be a chronic inflammatory disease of the airways. The roles of prostanoids, thromboxane A2 (TXA2) and the prostaglandins (PGs) in the pathogenesis and pathophysiology of asthma have fostered a wealth of studies but remain controversial. TXA2 and the bronchoconstrictor PGs, PGD2 and PGF2 alpha, are generated in greater amounts in asthmatic than in normal subjects. TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway microvascular leakage. It may participate in the thickening and the remodeling of the airway wall which may contribute to the airway hyperresponsiveness, a typical feature of asthma. Strategies for inhibition of TXA2 effects include antagonism of the TXA2 receptor (TP receptor) and inhibition of the thromboxane synthase. TP receptor antagonists could block the effects of all the bronchoconstrictor prostanoids because TXA2 as well as the bronchoconstrictor PGs act through activation of lung TP receptor. The recent development of specific and potent TP receptor antagonists and inhibitors of thromboxane synthase has provided tools to assess the role of TXA2 and broncho-constrictor PGs in the pathophysiology of asthma. SN - 0767-3981 UR - https://www.unboundmedicine.com/medline/citation/9182072/Thromboxane_A2_and_related_prostaglandins_in_airways_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0767-3981&date=1997&volume=11&issue=1&spage=2 DB - PRIME DP - Unbound Medicine ER -