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The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants.
Acta Paediatr 1997; 86(5):539-44AP

Abstract

OBJECTIVE

The objective of this study was to evaluate whether a regular formula for premature infants supplemented with nucleotides has any influence on plasma lipids and erythrocyte membrane fatty acids.

METHODS

Preterm infants fed either human milk supplemented with human milk protein (HM, n = 14), nucleotide-supplemented preterm formula (NF, n = 13), or a regular preterm formula (F, n = 13) were included in the study. The NF was supplemented with 18.2 mg cytidine monophosphate/l (CMP), 7.0 mg uridine monophosphate/l (UMP), 6.4 mg adenosine monophosphate/l (AMP), 3.0 mg inosine monophosphate/l (IMP) and 3.0 mg guanosine monophosphate/l (GMP).

RESULTS

There were significantly higher concentrations of triglycerides (TG) in infants fed NF compared to those fed F (191.42 +/- 79.58 vs 108.21 +/- 43.73, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma). Infants fed F had significantly lower concentrations of total cholesterol (94.34 +/- 11.71 vs 115.69 +/- 39.29, p < 0.01) and TG in plasma (108.21 +/- 43.73 vs 172.27 +/- 68.19, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma) when compared to HM-fed infants. There were no significant differences in any of the erythrocyte membrane fatty acids and total long-chain polyunsaturated fatty acids (LC-PUFA) between NF and F during the study period (6 weeks). Furthermore, total LC-PUFA and docosahexaenoic acid (DHA) concentrations in red blood cell were not significantly different when infants fed NF were compared to those fed HM. In contrast, however, infants fed F had significantly lower concentrations of total n-3 LC-PUFA (p < 0.01) and DHA (p < 0.01) than those found in HM-fed infants.

CONCLUSIONS

These results do not suggest an effect of nucleotides on the red blood cell LC-PUFA profile in preterm infants. However, the nucleotides may increase the concentrations of triglycerides in plasma.

Authors+Show Affiliations

Department of Pediatrics University of Lund, Malmö, Sweden.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9183496

Citation

Axelsson, I, et al. "The Influence of Dietary Nucleotides On Erythrocyte Membrane Fatty Acids and Plasma Lipids in Preterm Infants." Acta Paediatrica (Oslo, Norway : 1992), vol. 86, no. 5, 1997, pp. 539-44.
Axelsson I, Flodmark CE, Räihä N, et al. The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants. Acta Paediatr. 1997;86(5):539-44.
Axelsson, I., Flodmark, C. E., Räihä, N., Tacconi, M., Visentin, M., Minoli, I., ... Warm, A. (1997). The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants. Acta Paediatrica (Oslo, Norway : 1992), 86(5), pp. 539-44.
Axelsson I, et al. The Influence of Dietary Nucleotides On Erythrocyte Membrane Fatty Acids and Plasma Lipids in Preterm Infants. Acta Paediatr. 1997;86(5):539-44. PubMed PMID: 9183496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants. AU - Axelsson,I, AU - Flodmark,C E, AU - Räihä,N, AU - Tacconi,M, AU - Visentin,M, AU - Minoli,I, AU - Moro,G, AU - Warm,A, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 539 EP - 44 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 86 IS - 5 N2 - OBJECTIVE: The objective of this study was to evaluate whether a regular formula for premature infants supplemented with nucleotides has any influence on plasma lipids and erythrocyte membrane fatty acids. METHODS: Preterm infants fed either human milk supplemented with human milk protein (HM, n = 14), nucleotide-supplemented preterm formula (NF, n = 13), or a regular preterm formula (F, n = 13) were included in the study. The NF was supplemented with 18.2 mg cytidine monophosphate/l (CMP), 7.0 mg uridine monophosphate/l (UMP), 6.4 mg adenosine monophosphate/l (AMP), 3.0 mg inosine monophosphate/l (IMP) and 3.0 mg guanosine monophosphate/l (GMP). RESULTS: There were significantly higher concentrations of triglycerides (TG) in infants fed NF compared to those fed F (191.42 +/- 79.58 vs 108.21 +/- 43.73, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma). Infants fed F had significantly lower concentrations of total cholesterol (94.34 +/- 11.71 vs 115.69 +/- 39.29, p < 0.01) and TG in plasma (108.21 +/- 43.73 vs 172.27 +/- 68.19, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma) when compared to HM-fed infants. There were no significant differences in any of the erythrocyte membrane fatty acids and total long-chain polyunsaturated fatty acids (LC-PUFA) between NF and F during the study period (6 weeks). Furthermore, total LC-PUFA and docosahexaenoic acid (DHA) concentrations in red blood cell were not significantly different when infants fed NF were compared to those fed HM. In contrast, however, infants fed F had significantly lower concentrations of total n-3 LC-PUFA (p < 0.01) and DHA (p < 0.01) than those found in HM-fed infants. CONCLUSIONS: These results do not suggest an effect of nucleotides on the red blood cell LC-PUFA profile in preterm infants. However, the nucleotides may increase the concentrations of triglycerides in plasma. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/9183496/The_influence_of_dietary_nucleotides_on_erythrocyte_membrane_fatty_acids_and_plasma_lipids_in_preterm_infants_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0803-5253&amp;date=1997&amp;volume=86&amp;issue=5&amp;spage=539 DB - PRIME DP - Unbound Medicine ER -