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Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22.
Am J Med Genet. 1997 May 31; 74(3):238-46.AJ

Abstract

As part of the four-center NIMH Genetics Initiative on Bipolar Disorder we carried out a genomic scan of chromosomes 3, 5, 15, 16,17, and 22. Genotyping was performed on a set of 540 DNAs from 97 families, enriched for affected relative pairs and parents where available. We report here the results of the initial 74 markers that have been typed on this set of DNAs. The average distance between markers (theta) was 12.3 cM. Nonparametric analysis of excess allele sharing among affected sibling pairs used the SIBPAL program of the S.A.G.E. package to test three hierarchical models of affected status. D16S2619 gave some evidence of linkage to bipolar disorder, with P = 0.006 for Model II (in which bipolar 1, bipolar 2 and schizoaffective-bipolar type individuals are considered affected). Nearby markers also showed increased allele sharing. A second interesting region was toward the telomere of chromosome 5q, where D5S1456 and nearby markers showed increased allele sharing; for D5S1456, P = 0.05, 0.015 and 0.008 as the models of affected status become more broad. MOD score analysis also supported the possible presence of a susceptibility locus in this region of chromosome 5. A pair of adjacent markers on chromosome 3, D3S2405 and D3S3038, showed a modest increased allele sharing in the broad model. Several isolated markers had excess allele sharing at the P < 0.05 level under a single model. D15S217 showed a MOD score of 2.37 (P < 0.025). Multipoint analysis flagged the region of chromosome 22 around D22S533 as the most interesting. Thus, several regions showed modest evidence for linkage to bipolar disorder in this initial genomic scan of these chromosomes, including broad regions near previous reports of possible linkage.

Authors+Show Affiliations

Indiana University School of Medicine, Indianapolis 46202-5122, USA. edenberg@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9184305

Citation

Edenberg, H J., et al. "Initial Genomic Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22." American Journal of Medical Genetics, vol. 74, no. 3, 1997, pp. 238-46.
Edenberg HJ, Foroud T, Conneally PM, et al. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Am J Med Genet. 1997;74(3):238-46.
Edenberg, H. J., Foroud, T., Conneally, P. M., Sorbel, J. J., Carr, K., Crose, C., Willig, C., Zhao, J., Miller, M., Bowman, E., Mayeda, A., Rau, N. L., Smiley, C., Rice, J. P., Goate, A., Reich, T., Stine, O. C., McMahon, F., DePaulo, J. R., ... Nurnberger, J. I. (1997). Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. American Journal of Medical Genetics, 74(3), 238-46.
Edenberg HJ, et al. Initial Genomic Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22. Am J Med Genet. 1997 May 31;74(3):238-46. PubMed PMID: 9184305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. AU - Edenberg,H J, AU - Foroud,T, AU - Conneally,P M, AU - Sorbel,J J, AU - Carr,K, AU - Crose,C, AU - Willig,C, AU - Zhao,J, AU - Miller,M, AU - Bowman,E, AU - Mayeda,A, AU - Rau,N L, AU - Smiley,C, AU - Rice,J P, AU - Goate,A, AU - Reich,T, AU - Stine,O C, AU - McMahon,F, AU - DePaulo,J R, AU - Meyers,D, AU - Detera-Wadleigh,S D, AU - Goldin,L R, AU - Gershon,E S, AU - Blehar,M C, AU - Nurnberger,J I,Jr PY - 1997/5/31/pubmed PY - 2000/6/20/medline PY - 1997/5/31/entrez SP - 238 EP - 46 JF - American journal of medical genetics JO - Am. J. Med. Genet. VL - 74 IS - 3 N2 - As part of the four-center NIMH Genetics Initiative on Bipolar Disorder we carried out a genomic scan of chromosomes 3, 5, 15, 16,17, and 22. Genotyping was performed on a set of 540 DNAs from 97 families, enriched for affected relative pairs and parents where available. We report here the results of the initial 74 markers that have been typed on this set of DNAs. The average distance between markers (theta) was 12.3 cM. Nonparametric analysis of excess allele sharing among affected sibling pairs used the SIBPAL program of the S.A.G.E. package to test three hierarchical models of affected status. D16S2619 gave some evidence of linkage to bipolar disorder, with P = 0.006 for Model II (in which bipolar 1, bipolar 2 and schizoaffective-bipolar type individuals are considered affected). Nearby markers also showed increased allele sharing. A second interesting region was toward the telomere of chromosome 5q, where D5S1456 and nearby markers showed increased allele sharing; for D5S1456, P = 0.05, 0.015 and 0.008 as the models of affected status become more broad. MOD score analysis also supported the possible presence of a susceptibility locus in this region of chromosome 5. A pair of adjacent markers on chromosome 3, D3S2405 and D3S3038, showed a modest increased allele sharing in the broad model. Several isolated markers had excess allele sharing at the P < 0.05 level under a single model. D15S217 showed a MOD score of 2.37 (P < 0.025). Multipoint analysis flagged the region of chromosome 22 around D22S533 as the most interesting. Thus, several regions showed modest evidence for linkage to bipolar disorder in this initial genomic scan of these chromosomes, including broad regions near previous reports of possible linkage. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/9184305/Initial_genomic_scan_of_the_NIMH_genetics_initiative_bipolar_pedigrees:_chromosomes_3_5_15_16_17_and_22_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0148-7299&amp;date=1997&amp;volume=74&amp;issue=3&amp;spage=238 DB - PRIME DP - Unbound Medicine ER -