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Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review.
J Geriatr Psychiatry Neurol. 1997 Apr; 10(2):63-6.JG

Abstract

Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.

Authors+Show Affiliations

Creighton University/University of Nebraska Combined Department of Psychiatry, Omaha, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9188021

Citation

Widman, L P., et al. "Use of Clozapine to Treat Levodopa-induced Psychosis in Parkinson's Disease: Retrospective Review." Journal of Geriatric Psychiatry and Neurology, vol. 10, no. 2, 1997, pp. 63-6.
Widman LP, Burke WJ, Pfeiffer RF, et al. Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review. J Geriatr Psychiatry Neurol. 1997;10(2):63-6.
Widman, L. P., Burke, W. J., Pfeiffer, R. F., & McArthur-Campbell, D. (1997). Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review. Journal of Geriatric Psychiatry and Neurology, 10(2), 63-6.
Widman LP, et al. Use of Clozapine to Treat Levodopa-induced Psychosis in Parkinson's Disease: Retrospective Review. J Geriatr Psychiatry Neurol. 1997;10(2):63-6. PubMed PMID: 9188021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review. AU - Widman,L P, AU - Burke,W J, AU - Pfeiffer,R F, AU - McArthur-Campbell,D, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 63 EP - 6 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 10 IS - 2 N2 - Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/9188021/Use_of_clozapine_to_treat_levodopa_induced_psychosis_in_Parkinson's_disease:_retrospective_review_ L2 - https://journals.sagepub.com/doi/10.1177/089198879701000205?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -