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Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia.
Clin Invest Med. 1997 Jun; 20(3):162-70.CI

Abstract

OBJECTIVES

To determine whether, in individuals with hypercholesterolemia, substituting dietary soybean products for cows' milk products improves the plasma lipid profile and whether any change in the profile is due partially to soy oil.

DESIGN

Randomized 3-treatment crossover trial.

SETTING

Family practice clinics and an outpatient clinic in London, Ont.

PARTICIPANTS

Seventeen healthy men and 17 healthy women with elevated plasma levels of total and low-density-lipoprotein (LDL) cholesterol and with normal plasma levels of triglycerides.

INTERVENTIONS

Participants incorporated into their normal diet either 2% cows' milk products, soybean products or a combination of skim milk products and soy oil, each over period of 4 weeks, with 22-week wash-out periods. Plasma lipid profile, blood pressure and body weight were assessed after each dietary and wash-out period.

OUTCOME MEASURES

Plasma levels of total and lipoprotein cholesterol, plasma levels of triglycerides, apolipoprotein B and A1 levels, blood pressure and plasma lipid peroxidation.

RESULTS

The change in diet had no effect on body mass index, levels of apolipoproteins B and A1 and most plasma lipids. During the soybean period, the subjects' mean level of high-density-lipoprotein (HDL) cholesterol increased 9% (p < 0.04) and their mean LDL/HDL cholesterol ratio decreased 14% (p < 0.007). These effects were less pronounced during the skim milk/soy oil period. In the 24 subjects with the highest initial LDL cholesterol level and LDL/HDL cholesterol ratio, the mean LDL cholesterol level decreased 11% after the soybean period. In all subjects, changes in the LDL/HDL cholesterol ratio induced by a soybean diet were negatively correlated with the initial LDL/HDL cholesterol ratio and positively correlated with the initial HDL cholesterol level.

CONCLUSIONS

In people with hypercholesterolemia, the plasma lipid profile improved after treatment with a soybean-product diet, and this improvement was partially due to soy oil. The degree of responsiveness was associated with initial risk factors for coronary artery disease.

Authors+Show Affiliations

Department of Biochemistry, University of Western Ontario, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9189647

Citation

Kurowska, E M., et al. "Effects of Substituting Dietary Soybean Protein and Oil for Milk Protein and Fat in Subjects With Hypercholesterolemia." Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, vol. 20, no. 3, 1997, pp. 162-70.
Kurowska EM, Jordan J, Spence JD, et al. Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. Clin Invest Med. 1997;20(3):162-70.
Kurowska, E. M., Jordan, J., Spence, J. D., Wetmore, S., Piché, L. A., Radzikowski, M., Dandona, P., & Carroll, K. K. (1997). Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, 20(3), 162-70.
Kurowska EM, et al. Effects of Substituting Dietary Soybean Protein and Oil for Milk Protein and Fat in Subjects With Hypercholesterolemia. Clin Invest Med. 1997;20(3):162-70. PubMed PMID: 9189647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. AU - Kurowska,E M, AU - Jordan,J, AU - Spence,J D, AU - Wetmore,S, AU - Piché,L A, AU - Radzikowski,M, AU - Dandona,P, AU - Carroll,K K, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 162 EP - 70 JF - Clinical and investigative medicine. Medecine clinique et experimentale JO - Clin Invest Med VL - 20 IS - 3 N2 - OBJECTIVES: To determine whether, in individuals with hypercholesterolemia, substituting dietary soybean products for cows' milk products improves the plasma lipid profile and whether any change in the profile is due partially to soy oil. DESIGN: Randomized 3-treatment crossover trial. SETTING: Family practice clinics and an outpatient clinic in London, Ont. PARTICIPANTS: Seventeen healthy men and 17 healthy women with elevated plasma levels of total and low-density-lipoprotein (LDL) cholesterol and with normal plasma levels of triglycerides. INTERVENTIONS: Participants incorporated into their normal diet either 2% cows' milk products, soybean products or a combination of skim milk products and soy oil, each over period of 4 weeks, with 22-week wash-out periods. Plasma lipid profile, blood pressure and body weight were assessed after each dietary and wash-out period. OUTCOME MEASURES: Plasma levels of total and lipoprotein cholesterol, plasma levels of triglycerides, apolipoprotein B and A1 levels, blood pressure and plasma lipid peroxidation. RESULTS: The change in diet had no effect on body mass index, levels of apolipoproteins B and A1 and most plasma lipids. During the soybean period, the subjects' mean level of high-density-lipoprotein (HDL) cholesterol increased 9% (p < 0.04) and their mean LDL/HDL cholesterol ratio decreased 14% (p < 0.007). These effects were less pronounced during the skim milk/soy oil period. In the 24 subjects with the highest initial LDL cholesterol level and LDL/HDL cholesterol ratio, the mean LDL cholesterol level decreased 11% after the soybean period. In all subjects, changes in the LDL/HDL cholesterol ratio induced by a soybean diet were negatively correlated with the initial LDL/HDL cholesterol ratio and positively correlated with the initial HDL cholesterol level. CONCLUSIONS: In people with hypercholesterolemia, the plasma lipid profile improved after treatment with a soybean-product diet, and this improvement was partially due to soy oil. The degree of responsiveness was associated with initial risk factors for coronary artery disease. SN - 0147-958X UR - https://www.unboundmedicine.com/medline/citation/9189647/Effects_of_substituting_dietary_soybean_protein_and_oil_for_milk_protein_and_fat_in_subjects_with_hypercholesterolemia_ L2 - http://www.diseaseinfosearch.org/result/3550 DB - PRIME DP - Unbound Medicine ER -