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[One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer].
Med Clin (Barc). 1997 Apr 12; 108(14):524-9.MC

Abstract

BACKGROUND

To evaluate the efficacy of one-week therapy with omeprazole, clarithromycin and amoxycillin in eradicating Helicobacter pylori and healing duodenal ulcer.

PATIENTS AND METHODS

One-hundred and thirty-four consecutive duodenal ulcer patients (mean age 47 +/- 13 yrs, 66% males) with H. pylori infection were prospectively studied. At endoscopy, biopsies from both gastric antrum and body were obtained for histologic study (H/E). A 15C-urea breath test was also performed in 98 patients. Omeprazole 20 mg b.i.d., amoxycillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. were administered only for 1 week, and no therapy was administered thereafter. Endoscopy with biopsies and breath test were repeated 1 month after completing therapy.

RESULTS

Eradication was achieved in 87.3% of patients (n = 93; 95% CI = 82-93%). In the multivariate analysis the variables which influenced H. pylori eradication were: time of evolution of ulcer disease (p = 0.002) and active chronic gastritis in the antrum (p = 0.04) (chi 2 model = 15.8; p = 0.001). Ulcer healing was demonstrated in 89.5% of patients (84-95%), and healing rate was higher when eradication was achieved (94%; 90-98%) than in H. pylori-positive patients (59%; 36-78%) (p < 0.001). In the multivariate analysis the variables which influenced ulcer healing were: age (p = 0.02) and H. pylori eradication (p = 0.001) (chi 2 model = 21.2; p = 0.0001). An improvement of histologic gastritis was observed when eradication was achieved (p < 0.001). Compliance of therapy was complete in all patients but one and no relevant adverse effects were reported.

CONCLUSION

One-week triple therapy with omeprazole, clarithromycin and amoxycillin administered on a twice daily basis achieves a high efficacy in eradicating H. pylori and healing duodenal ulcer. Moreover, this therapy regimen is simple and is associated with a low incidence of adverse effects and a low cost.

Authors+Show Affiliations

Servicio de Gastroenterología, Hospital Ramón y Cajal, Madrid.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

spa

PubMed ID

9190436

Citation

Gisbert, J P., et al. "[One-week Treatment With Omeprazole, Clarithromycin and Amoxicillin: High Efficacy in the Eradication of Helicobacter Pylori and Cicatrization of Duodenal Ulcer]." Medicina Clinica, vol. 108, no. 14, 1997, pp. 524-9.
Gisbert JP, Mur M, Boixeda D, et al. [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. Med Clin (Barc). 1997;108(14):524-9.
Gisbert, J. P., Mur, M., Boixeda, D., Ceña, G., Martín de Argila, C., Alvarez Baleriola, I., Abraira, V., & García Plaza, A. (1997). [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. Medicina Clinica, 108(14), 524-9.
Gisbert JP, et al. [One-week Treatment With Omeprazole, Clarithromycin and Amoxicillin: High Efficacy in the Eradication of Helicobacter Pylori and Cicatrization of Duodenal Ulcer]. Med Clin (Barc). 1997 Apr 12;108(14):524-9. PubMed PMID: 9190436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. AU - Gisbert,J P, AU - Mur,M, AU - Boixeda,D, AU - Ceña,G, AU - Martín de Argila,C, AU - Alvarez Baleriola,I, AU - Abraira,V, AU - García Plaza,A, PY - 1997/4/12/pubmed PY - 1997/4/12/medline PY - 1997/4/12/entrez SP - 524 EP - 9 JF - Medicina clinica JO - Med Clin (Barc) VL - 108 IS - 14 N2 - BACKGROUND: To evaluate the efficacy of one-week therapy with omeprazole, clarithromycin and amoxycillin in eradicating Helicobacter pylori and healing duodenal ulcer. PATIENTS AND METHODS: One-hundred and thirty-four consecutive duodenal ulcer patients (mean age 47 +/- 13 yrs, 66% males) with H. pylori infection were prospectively studied. At endoscopy, biopsies from both gastric antrum and body were obtained for histologic study (H/E). A 15C-urea breath test was also performed in 98 patients. Omeprazole 20 mg b.i.d., amoxycillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. were administered only for 1 week, and no therapy was administered thereafter. Endoscopy with biopsies and breath test were repeated 1 month after completing therapy. RESULTS: Eradication was achieved in 87.3% of patients (n = 93; 95% CI = 82-93%). In the multivariate analysis the variables which influenced H. pylori eradication were: time of evolution of ulcer disease (p = 0.002) and active chronic gastritis in the antrum (p = 0.04) (chi 2 model = 15.8; p = 0.001). Ulcer healing was demonstrated in 89.5% of patients (84-95%), and healing rate was higher when eradication was achieved (94%; 90-98%) than in H. pylori-positive patients (59%; 36-78%) (p < 0.001). In the multivariate analysis the variables which influenced ulcer healing were: age (p = 0.02) and H. pylori eradication (p = 0.001) (chi 2 model = 21.2; p = 0.0001). An improvement of histologic gastritis was observed when eradication was achieved (p < 0.001). Compliance of therapy was complete in all patients but one and no relevant adverse effects were reported. CONCLUSION: One-week triple therapy with omeprazole, clarithromycin and amoxycillin administered on a twice daily basis achieves a high efficacy in eradicating H. pylori and healing duodenal ulcer. Moreover, this therapy regimen is simple and is associated with a low incidence of adverse effects and a low cost. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/9190436/[One_week_treatment_with_omeprazole_clarithromycin_and_amoxicillin:_high_efficacy_in_the_eradication_of_Helicobacter_pylori_and_cicatrization_of_duodenal_ulcer]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -