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Environmental risk factors and Parkinson's disease: a case-control study in Taiwan.
Neurology. 1997 Jun; 48(6):1583-8.Neur

Abstract

To explore environmental risk factors for Parkinson's disease (PD) in Taiwan, we investigated 120 patients with PD and 240 hospital control subjects matched with patients on age (+/-2 years) and sex. Based on a structured open-ended questionnaire, we carried out standardized interviews to obtain history of exposure to environmental factors, including place of residence, source of drinking water, and environmental and occupational exposures to various agricultural chemicals. In the univariate analysis, the history of living in a rural environment, farming, use of herbicides/pesticides, and use of paraquat were associated with an increased PD risk in a dose-response relationship. After adjustment for multiple risk factors through conditional logistic regression, the biological gradient between PD and previous uses of herbicides/pesticides and paraquat remained significant. The PD risk was greater among subjects who had used paraquat and other herbicides/pesticides than those who had used herbicides/pesticides other than paraquat. There were no significant differences in occupational exposures to chemicals, heavy metals, and minerals between PD patients and matched control subjects. The duration of drinking well water and alcohol consumption was not significantly associated with PD. There was an inverse relationship between cigarette smoking and PD. Environmental factors, especially exposures to paraquat and herbicides/pesticides, may play important roles in the development of PD in Taiwan.

Authors+Show Affiliations

Department of Neurology, National Taiwan University Hospital, Taipei.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9191770

Citation

Liou, H H., et al. "Environmental Risk Factors and Parkinson's Disease: a Case-control Study in Taiwan." Neurology, vol. 48, no. 6, 1997, pp. 1583-8.
Liou HH, Tsai MC, Chen CJ, et al. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology. 1997;48(6):1583-8.
Liou, H. H., Tsai, M. C., Chen, C. J., Jeng, J. S., Chang, Y. C., Chen, S. Y., & Chen, R. C. (1997). Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology, 48(6), 1583-8.
Liou HH, et al. Environmental Risk Factors and Parkinson's Disease: a Case-control Study in Taiwan. Neurology. 1997;48(6):1583-8. PubMed PMID: 9191770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. AU - Liou,H H, AU - Tsai,M C, AU - Chen,C J, AU - Jeng,J S, AU - Chang,Y C, AU - Chen,S Y, AU - Chen,R C, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 1583 EP - 8 JF - Neurology JO - Neurology VL - 48 IS - 6 N2 - To explore environmental risk factors for Parkinson's disease (PD) in Taiwan, we investigated 120 patients with PD and 240 hospital control subjects matched with patients on age (+/-2 years) and sex. Based on a structured open-ended questionnaire, we carried out standardized interviews to obtain history of exposure to environmental factors, including place of residence, source of drinking water, and environmental and occupational exposures to various agricultural chemicals. In the univariate analysis, the history of living in a rural environment, farming, use of herbicides/pesticides, and use of paraquat were associated with an increased PD risk in a dose-response relationship. After adjustment for multiple risk factors through conditional logistic regression, the biological gradient between PD and previous uses of herbicides/pesticides and paraquat remained significant. The PD risk was greater among subjects who had used paraquat and other herbicides/pesticides than those who had used herbicides/pesticides other than paraquat. There were no significant differences in occupational exposures to chemicals, heavy metals, and minerals between PD patients and matched control subjects. The duration of drinking well water and alcohol consumption was not significantly associated with PD. There was an inverse relationship between cigarette smoking and PD. Environmental factors, especially exposures to paraquat and herbicides/pesticides, may play important roles in the development of PD in Taiwan. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/9191770/Environmental_risk_factors_and_Parkinson's_disease:_a_case_control_study_in_Taiwan_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9191770.ui DB - PRIME DP - Unbound Medicine ER -