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The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women.
Eur J Clin Nutr 1997; 51(6):394-9EJ

Abstract

OBJECTIVE

To investigate the effects of high and low sodium diets on urinary calcium, bone turnover and calcium absorption in pre and postmenopausal women.

DESIGN

Experimental, prospective and longitudinal study.

SETTING

Samples were taken at the hospital and the diets were followed at home.

SUBJECTS

Volunteers were recruited from the hospital and were either hospital staff or post-graduate students. No volunteers failed to complete the study but one was omitted from analysis due to lack of compliance.

INTERVENTIONS

Eleven healthy premenopausal women aged 22-47 y and 11 healthy postmenopausal women ages 45-70 y followed a high (300 mmol/d) and a low (50 mmol/d) sodium diet for one week each. On the 7th day of each diet, blood and urine samples were taken.

RESULTS

On the high sodium diet 24 h urinary sodium and calcium values relative to creatinine were significantly higher for all subjects (P < 0.05). Postmenopausal women on the high sodium diet had biochemical evidence of increased bone resorption in relation to the low sodium diet. However in premenopausal women there was no such change. Calcium absorption did not change significantly in either group.

CONCLUSIONS

It appears that postmenopausal, but not premenopausal, women respond to a high sodium diet by an increase in bone resorption which may lead to reduced bone density.

SPONSORSHIP

Arthritis and Rheumatism Council Project Grant R44.

Authors+Show Affiliations

University of Sheffield, Northern General Hospital, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9192198

Citation

Evans, C E., et al. "The Effect of Dietary Sodium On Calcium Metabolism in Premenopausal and Postmenopausal Women." European Journal of Clinical Nutrition, vol. 51, no. 6, 1997, pp. 394-9.
Evans CE, Chughtai AY, Blumsohn A, et al. The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women. Eur J Clin Nutr. 1997;51(6):394-9.
Evans, C. E., Chughtai, A. Y., Blumsohn, A., Giles, M., & Eastell, R. (1997). The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women. European Journal of Clinical Nutrition, 51(6), pp. 394-9.
Evans CE, et al. The Effect of Dietary Sodium On Calcium Metabolism in Premenopausal and Postmenopausal Women. Eur J Clin Nutr. 1997;51(6):394-9. PubMed PMID: 9192198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women. AU - Evans,C E, AU - Chughtai,A Y, AU - Blumsohn,A, AU - Giles,M, AU - Eastell,R, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 394 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 51 IS - 6 N2 - OBJECTIVE: To investigate the effects of high and low sodium diets on urinary calcium, bone turnover and calcium absorption in pre and postmenopausal women. DESIGN: Experimental, prospective and longitudinal study. SETTING: Samples were taken at the hospital and the diets were followed at home. SUBJECTS: Volunteers were recruited from the hospital and were either hospital staff or post-graduate students. No volunteers failed to complete the study but one was omitted from analysis due to lack of compliance. INTERVENTIONS: Eleven healthy premenopausal women aged 22-47 y and 11 healthy postmenopausal women ages 45-70 y followed a high (300 mmol/d) and a low (50 mmol/d) sodium diet for one week each. On the 7th day of each diet, blood and urine samples were taken. RESULTS: On the high sodium diet 24 h urinary sodium and calcium values relative to creatinine were significantly higher for all subjects (P < 0.05). Postmenopausal women on the high sodium diet had biochemical evidence of increased bone resorption in relation to the low sodium diet. However in premenopausal women there was no such change. Calcium absorption did not change significantly in either group. CONCLUSIONS: It appears that postmenopausal, but not premenopausal, women respond to a high sodium diet by an increase in bone resorption which may lead to reduced bone density. SPONSORSHIP: Arthritis and Rheumatism Council Project Grant R44. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9192198/The_effect_of_dietary_sodium_on_calcium_metabolism_in_premenopausal_and_postmenopausal_women_ L2 - https://medlineplus.gov/sodium.html DB - PRIME DP - Unbound Medicine ER -