TY - JOUR T1 - Dietary antioxidants and Parkinson disease. The Rotterdam Study. AU - de Rijk,M C, AU - Breteler,M M, AU - den Breeijen,J H, AU - Launer,L J, AU - Grobbee,D E, AU - van der Meché,F G, AU - Hofman,A, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 762 EP - 5 JF - Archives of neurology JO - Arch. Neurol. VL - 54 IS - 6 N2 - OBJECTIVE: To investigate whether high dietary intake of antioxidants decreases the risk of Parkinson disease (PD). SETTING: The community-based Rotterdam Study, the Netherlands. DESIGN: The cross-sectional study formed part of a large community-based study in which all participants were individually screened for parkinsonism and were administered a semiquantitative food frequency questionnaire. The study population consisted of 5342 independently living individuals without dementia between 55 and 95 years of age, including 31 participants with PD (Hoehn-Yahr stages 1-3). RESULTS: The odds ratio for PD was 0.5 (95% confidence interval [CI], 0.2-0.9) per 10-mg daily dietary vitamin E intake, 0.6 (95% CI, 0.3-1.3) per 1-mg beta carotene intake, 0.9 (95% CI, 0.4-1.9) per 100-mg vitamin C intake, and 0.9 (95% CI, 0.7-1.2) per 10-mg flavonoids intake, all adjusted for age, sex, smoking habits, and energy intake. The association with vitamin E intake was dose dependent (P for trend = .03). To assess whether the association was different in participants with more advanced disease, we excluded those with PD who had a Hoehn-Yahr stage of 2.5 or 3. This did not fundamentally alter the results. CONCLUSION: Our data suggest that a high intake of dietary vitamin E may protect against the occurrence of PD. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/9193212/Dietary_antioxidants_and_Parkinson_disease__The_Rotterdam_Study_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/54/pg/762 DB - PRIME DP - Unbound Medicine ER -