Tags

Type your tag names separated by a space and hit enter

Increased prevalence of Helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations.
J Gastroenterol Hepatol 1997; 12(6):425-8JG

Abstract

Previous data on the association of Helicobacter pylori infection with gastric cancer by demographic or histological features are inconsistent due to a univariate analysis of limited case numbers. The aim of the present study was to determine such an association by the use of a large series of patients and multiple variables analysis. The serum IgG antibodies against H. pylori were measured in 397 patients with histologically verified gastric cancer. A multiple logistic regression analysis was used to define the association between seropositivity and demographic or tumour characteristics of gastric cancer. The overall seropositivity of H. pylori was 63%. In univariate analysis, the prevalence was significantly lower among patients with cardia (50%) or diffuse-type (56.6%) cancers than those with non-cardia (64.8%) or intestinal-type (70.3%) cancer (P < 0.05 and P < 0.01, respectively). There was no statistical difference between H. pylori infection rate and gender, age or tumour stage. A multiple logistic regression analysis showed tumour location and histology remained significant factors associated with seropositivity of H. pylori with an odds ratio of approximately 2.0. Analysis of combined histology and location revealed that patients with intestinal-type cancer at non-cardia locations had the highest odds ratio of 3.93 (95% confidence interval (CI): 1.55-10.0) compared with the lowest odds ratio of 0.69 (95% CI: 0.30-1.62) in diffuse cardia cancer (P < 0.005). Our data indicate H. pylori infection in gastric cancer is independently affected by the histological subtype and by tumour location.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University Hospital, Taipei.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9195398

Citation

Wu, M S., et al. "Increased Prevalence of Helicobacter Pylori Infection Among Patients Affected With Intestinal-type Gastric Cancer at Non-cardiac Locations." Journal of Gastroenterology and Hepatology, vol. 12, no. 6, 1997, pp. 425-8.
Wu MS, Chen SY, Shun CT, et al. Increased prevalence of Helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations. J Gastroenterol Hepatol. 1997;12(6):425-8.
Wu, M. S., Chen, S. Y., Shun, C. T., Lee, W. J., Wang, H. P., Wang, T. H., ... Lin, J. T. (1997). Increased prevalence of Helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations. Journal of Gastroenterology and Hepatology, 12(6), pp. 425-8.
Wu MS, et al. Increased Prevalence of Helicobacter Pylori Infection Among Patients Affected With Intestinal-type Gastric Cancer at Non-cardiac Locations. J Gastroenterol Hepatol. 1997;12(6):425-8. PubMed PMID: 9195398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalence of Helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations. AU - Wu,M S, AU - Chen,S Y, AU - Shun,C T, AU - Lee,W J, AU - Wang,H P, AU - Wang,T H, AU - Chen,C J, AU - Lin,J T, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 425 EP - 8 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 12 IS - 6 N2 - Previous data on the association of Helicobacter pylori infection with gastric cancer by demographic or histological features are inconsistent due to a univariate analysis of limited case numbers. The aim of the present study was to determine such an association by the use of a large series of patients and multiple variables analysis. The serum IgG antibodies against H. pylori were measured in 397 patients with histologically verified gastric cancer. A multiple logistic regression analysis was used to define the association between seropositivity and demographic or tumour characteristics of gastric cancer. The overall seropositivity of H. pylori was 63%. In univariate analysis, the prevalence was significantly lower among patients with cardia (50%) or diffuse-type (56.6%) cancers than those with non-cardia (64.8%) or intestinal-type (70.3%) cancer (P < 0.05 and P < 0.01, respectively). There was no statistical difference between H. pylori infection rate and gender, age or tumour stage. A multiple logistic regression analysis showed tumour location and histology remained significant factors associated with seropositivity of H. pylori with an odds ratio of approximately 2.0. Analysis of combined histology and location revealed that patients with intestinal-type cancer at non-cardia locations had the highest odds ratio of 3.93 (95% confidence interval (CI): 1.55-10.0) compared with the lowest odds ratio of 0.69 (95% CI: 0.30-1.62) in diffuse cardia cancer (P < 0.005). Our data indicate H. pylori infection in gastric cancer is independently affected by the histological subtype and by tumour location. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/9195398/Increased_prevalence_of_Helicobacter_pylori_infection_among_patients_affected_with_intestinal_type_gastric_cancer_at_non_cardiac_locations_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0815-9319&amp;date=1997&amp;volume=12&amp;issue=6&amp;spage=425 DB - PRIME DP - Unbound Medicine ER -